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- W3144955683 abstract "Objective The correlation were studied between testosterone 5-alpha-reductase Ⅱ (SRD5A2) gene polymorphisms and prognosis factors. Methods V89L and A49T variants was identified with Mwo1 and Rsal. The differences of V89L and A49T between cancer of prostate (CaP) and benign prostatic hyperplusia (BPH) were studied. In addition, we also researched the association of polymorphisms with age of onset, free prostate specific antigen(FPSA) , total PSA (TPSA) , FPSA/TPSA(F/T) , Gleason score, and T stage in cancer group. Results We found no differences of V89L and A49T polymorphisms between CaP and BPH. In CaP group the A49T variant was associated with lower age of onset ( P = 0. 03) and higher Gleason score (P = 0. 015 ). There were no differences between VV and VL + LL polymorphisms with any of the characteristics studied. When the characteristics above were regarded as two-level discrete variable , there were no differences by A49T and V89Lvariants. Conclusion In CaP group, the AT + TT genotype was perhaps associated with poor prognosis. VL + LL genotype has no relation with prognosis ." @default.
- W3144955683 created "2021-04-13" @default.
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- W3144955683 date "2004-01-01" @default.
- W3144955683 modified "2023-09-23" @default.
- W3144955683 title "Association of polymorphisms in testosterone 5-alpha-reductase II genotype and prognosis factors of prostate cancer." @default.
- W3144955683 hasPublicationYear "2004" @default.
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