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- W3144975504 endingPage "129" @default.
- W3144975504 startingPage "115" @default.
- W3144975504 abstract "Melatonin, an indolamine mainly released from the pineal gland, is associated with many biological functions, namely, the modulation of circadian and seasonal rhythms, sleep inducer, regulator of energy metabolism, antioxidant, and anticarcinogenic. Although several pieces of evidence also recognize the influence of melatonin in the reproductive physiology, the crosstalk between melatonin and sex hormones is not clear. Here, we review the effects of sex differences in the circulating levels of melatonin and update the current knowledge on the link between sex hormones and melatonin. Furthermore, we explore the effects of melatonin on gonadal steroidogenesis and hormonal control in females. The literature review shows that despite the strong evidence that sex differences impact on the circadian profiles of melatonin, reports are still considerably ambiguous, and these differences may arise from several factors, like the use of contraceptive pills, hormonal status, and sleep deprivation. Furthermore, there has been an inconclusive debate about the characteristics of the reciprocal relationship between melatonin and reproductive hormones. In this regard, there is evidence for the role of melatonin in gonadal steroidogenesis brought about by research that shows that melatonin affects multiple transduction pathways that modulate Sertoli cell physiology and consequently spermatogenesis, and also estrogen and progesterone production. From the outcome of our research, it is possible to conclude that understanding the correlation between melatonin and reproductive hormones is crucial for the correction of several complications occurring during pregnancy, like preeclampsia, and for the control of climacteric symptoms." @default.
- W3144975504 created "2021-04-13" @default.
- W3144975504 creator A5006206733 @default.
- W3144975504 creator A5006707942 @default.
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- W3144975504 creator A5078117648 @default.
- W3144975504 creator A5091038630 @default.
- W3144975504 creator A5091060147 @default.
- W3144975504 date "2021-03-26" @default.
- W3144975504 modified "2023-10-16" @default.
- W3144975504 title "The Crosstalk between Melatonin and Sex Steroid Hormones" @default.
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