Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144977637> ?p ?o ?g. }
- W3144977637 endingPage "788" @default.
- W3144977637 startingPage "775" @default.
- W3144977637 abstract "We interrogated at nucleotide resolution the spatiotemporal order of chromatin changes that occur immediately following a site-specific double-strand break (DSB) upstream of the PHO5 locus and its subsequent repair by nonhomologous end joining (NHEJ). We observed the immediate eviction of a nucleosome flanking the break and the repositioning of adjacent nucleosomes away from the break. These early chromatin events were independent of the end-processing Mre11-Rad50-Xrs2 (MRX) complex and preceded the MRX-dependent broad eviction of histones and DNA end-resectioning that extends up to ∼8 kb away from the break. We also examined the temporal dynamics of NHEJ-mediated repair in a G1-arrested population. Concomitant with DSB repair by NHEJ, we observed the redeposition and precise repositioning of nucleosomes at their originally occupied positions. This re-establishment of the prelesion chromatin landscape suggests that a DNA replication-independent mechanism exists to preserve epigenome organization following DSB repair." @default.
- W3144977637 created "2021-04-13" @default.
- W3144977637 creator A5024558337 @default.
- W3144977637 creator A5026273992 @default.
- W3144977637 creator A5048113506 @default.
- W3144977637 creator A5052498824 @default.
- W3144977637 creator A5056347685 @default.
- W3144977637 creator A5070421009 @default.
- W3144977637 creator A5079793191 @default.
- W3144977637 creator A5085085286 @default.
- W3144977637 date "2021-04-02" @default.
- W3144977637 modified "2023-10-14" @default.
- W3144977637 title "Local nucleosome dynamics and eviction following a double-strand break are reversible by NHEJ-mediated repair in the absence of DNA replication" @default.
- W3144977637 cites W1543815058 @default.
- W3144977637 cites W1574967994 @default.
- W3144977637 cites W160239957 @default.
- W3144977637 cites W1627029737 @default.
- W3144977637 cites W1637308698 @default.
- W3144977637 cites W1644052592 @default.
- W3144977637 cites W1763161027 @default.
- W3144977637 cites W1965341449 @default.
- W3144977637 cites W1965835313 @default.
- W3144977637 cites W1972068359 @default.
- W3144977637 cites W1972303909 @default.
- W3144977637 cites W1974987314 @default.
- W3144977637 cites W1978054036 @default.
- W3144977637 cites W1980725176 @default.
- W3144977637 cites W1983218764 @default.
- W3144977637 cites W1989136612 @default.
- W3144977637 cites W1992005588 @default.
- W3144977637 cites W1992875057 @default.
- W3144977637 cites W1993026474 @default.
- W3144977637 cites W2003460222 @default.
- W3144977637 cites W2003581594 @default.
- W3144977637 cites W2010578066 @default.
- W3144977637 cites W2012144576 @default.
- W3144977637 cites W2013083223 @default.
- W3144977637 cites W2017275209 @default.
- W3144977637 cites W2019025864 @default.
- W3144977637 cites W2019394964 @default.
- W3144977637 cites W2021029128 @default.
- W3144977637 cites W2029895295 @default.
- W3144977637 cites W2031292590 @default.
- W3144977637 cites W2034269086 @default.
- W3144977637 cites W2034746516 @default.
- W3144977637 cites W2036546456 @default.
- W3144977637 cites W2037043512 @default.
- W3144977637 cites W2037452624 @default.
- W3144977637 cites W2045504097 @default.
- W3144977637 cites W2046723844 @default.
- W3144977637 cites W2051003586 @default.
- W3144977637 cites W2061737909 @default.
- W3144977637 cites W2064840027 @default.
- W3144977637 cites W2068288569 @default.
- W3144977637 cites W2074366688 @default.
- W3144977637 cites W2079047745 @default.
- W3144977637 cites W2081702399 @default.
- W3144977637 cites W2083022228 @default.
- W3144977637 cites W2083740738 @default.
- W3144977637 cites W2086333179 @default.
- W3144977637 cites W2088327962 @default.
- W3144977637 cites W2090438862 @default.
- W3144977637 cites W2092202372 @default.
- W3144977637 cites W2094020226 @default.
- W3144977637 cites W2099798537 @default.
- W3144977637 cites W2102604046 @default.
- W3144977637 cites W2103926523 @default.
- W3144977637 cites W2105989207 @default.
- W3144977637 cites W2106466938 @default.
- W3144977637 cites W2110143309 @default.
- W3144977637 cites W2118233114 @default.
- W3144977637 cites W2122366486 @default.
- W3144977637 cites W2124985265 @default.
- W3144977637 cites W2131604076 @default.
- W3144977637 cites W2131978108 @default.
- W3144977637 cites W2141312910 @default.
- W3144977637 cites W2145583284 @default.
- W3144977637 cites W2164995160 @default.
- W3144977637 cites W2167365794 @default.
- W3144977637 cites W2169333620 @default.
- W3144977637 cites W2170509903 @default.
- W3144977637 cites W2259836065 @default.
- W3144977637 cites W2319825622 @default.
- W3144977637 cites W2341420010 @default.
- W3144977637 cites W2409457521 @default.
- W3144977637 cites W2526127825 @default.
- W3144977637 cites W2547049198 @default.
- W3144977637 cites W2568885441 @default.
- W3144977637 cites W2570439282 @default.
- W3144977637 cites W2576734941 @default.
- W3144977637 cites W2584565811 @default.
- W3144977637 cites W2606660232 @default.
- W3144977637 cites W2736244299 @default.
- W3144977637 cites W2778217919 @default.
- W3144977637 cites W2953356922 @default.
- W3144977637 cites W3100125909 @default.
- W3144977637 cites W3154384473 @default.
- W3144977637 cites W4211163486 @default.