FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144985489> ?p ?o ?g. }

• W3144985489 endingPage "309" @default.
• W3144985489 startingPage "304" @default.
• W3144985489 abstract "Purpose: To investigate the characteristic thoracic multidetector computed tomography (MDCT) findings of dedicator of cytokinesis 8 (DOCK8) deficiency, a rare autosomal recessive form of hyperimmunoglobulin E syndrome, in children. Materials and Methods: All pediatric patients (age 18 y and below) with a known diagnosis of DOCK8 deficiency based on genetic testing who underwent thoracic MDCT studies from November 2004 to November 2020 were included. Two pediatric radiologists independently evaluated MDCT studies for the presence of thoracic abnormalities in the lung [ground-glass opacity (GGO), consolidation, pulmonary nodule, mass, cyst, and bronchiectasis], pleura (pleural effusion and pneumothorax), and mediastinum (lymphadenopathy). When a lung abnormality was present, laterality, distribution (upper, middle, and lower lung zone), and extent were also evaluated. When a pleural abnormality was identified, laterality and size of the abnormality were also assessed. When mediastinal lymphadenopathy was present, its location and size were also evaluated. Interobserver agreement between two independent reviewers was evaluated with κ statistics. Results: In all, 17 thoracic MDCT studies from 17 individual pediatric patients [5 males (29%) and 12 females (71%); mean age: 7.4 y; SD: 3.7; range: 1 to 13 y] comprised the final study population. Among 17 thoracic MDCT studies, 11 studies (65%) were performed with intravenous contrast (IV) and the remaining 6 MDCT studies (35%) were obtained without IV contrast. Bilateral bronchiectasis (11/17; 65%) with a middle lung zone predominance (8/11; 73%) was the most frequently detected lung abnormality, followed by GGO in 9/17 patients (53%). Among 11 contrast-enhanced MDCT studies, the majority (9 patients, 82%) had mediastinal lymphadenopathy. There was excellent interobserver κ agreement between 2 independent reviewers for detecting abnormalities on thoracic MDCT studies (κ>0.90). Conclusion: Children with DOCK8 deficiency have characteristic thoracic MDCT findings, including bilateral bronchiectasis with a middle lung zone predominance, GGO, and mediastinal lymphadenopathy. When these characteristic thoracic MDCT findings are detected, although rare, DOCK8 deficiency should be considered as a possible underlying diagnosis in the pediatric population." @default.
• W3144985489 created "2021-04-13" @default.
• W3144985489 creator A5011465271 @default.
• W3144985489 creator A5018313534 @default.
• W3144985489 creator A5033198329 @default.
• W3144985489 creator A5055561412 @default.
• W3144985489 creator A5069455100 @default.
• W3144985489 creator A5086617359 @default.
• W3144985489 date "2021-03-22" @default.
• W3144985489 modified "2023-10-14" @default.
• W3144985489 title "Thoracic Multidetector Computed Tomography Findings of Dedicator of Cytokinesis 8 Deficiency in Children" @default.
• W3144985489 cites W1969777904 @default.
• W3144985489 cites W1980315486 @default.
• W3144985489 cites W1983670187 @default.
• W3144985489 cites W1994992814 @default.
• W3144985489 cites W2050152285 @default.
• W3144985489 cites W2055234427 @default.
• W3144985489 cites W2093340532 @default.
• W3144985489 cites W2102634410 @default.
• W3144985489 cites W2105207791 @default.
• W3144985489 cites W2142127956 @default.
• W3144985489 cites W2315353015 @default.
• W3144985489 cites W2523309544 @default.
• W3144985489 cites W2626877998 @default.
• W3144985489 cites W3008180115 @default.
• W3144985489 doi "https://doi.org/10.1097/rti.0000000000000587" @default.
• W3144985489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34260161" @default.
• W3144985489 hasPublicationYear "2021" @default.
• W3144985489 type Work @default.
• W3144985489 sameAs 3144985489 @default.
• W3144985489 citedByCount "2" @default.
• W3144985489 countsByYear W31449854892022 @default.
• W3144985489 countsByYear W31449854892023 @default.
• W3144985489 crossrefType "journal-article" @default.
• W3144985489 hasAuthorship W3144985489A5011465271 @default.
• W3144985489 hasAuthorship W3144985489A5018313534 @default.
• W3144985489 hasAuthorship W3144985489A5033198329 @default.
• W3144985489 hasAuthorship W3144985489A5055561412 @default.
• W3144985489 hasAuthorship W3144985489A5069455100 @default.
• W3144985489 hasAuthorship W3144985489A5086617359 @default.
• W3144985489 hasConcept C118552586 @default.
• W3144985489 hasConcept C126322002 @default.
• W3144985489 hasConcept C126838900 @default.
• W3144985489 hasConcept C142724271 @default.
• W3144985489 hasConcept C16568411 @default.
• W3144985489 hasConcept C2776313322 @default.
• W3144985489 hasConcept C2777714996 @default.
• W3144985489 hasConcept C2778741246 @default.
• W3144985489 hasConcept C2779126056 @default.
• W3144985489 hasConcept C2779379686 @default.
• W3144985489 hasConcept C2779634585 @default.
• W3144985489 hasConcept C2779889316 @default.
• W3144985489 hasConcept C50965678 @default.
• W3144985489 hasConcept C544519230 @default.
• W3144985489 hasConcept C71924100 @default.
• W3144985489 hasConceptScore W3144985489C118552586 @default.
• W3144985489 hasConceptScore W3144985489C126322002 @default.
• W3144985489 hasConceptScore W3144985489C126838900 @default.
• W3144985489 hasConceptScore W3144985489C142724271 @default.
• W3144985489 hasConceptScore W3144985489C16568411 @default.
• W3144985489 hasConceptScore W3144985489C2776313322 @default.
• W3144985489 hasConceptScore W3144985489C2777714996 @default.
• W3144985489 hasConceptScore W3144985489C2778741246 @default.
• W3144985489 hasConceptScore W3144985489C2779126056 @default.
• W3144985489 hasConceptScore W3144985489C2779379686 @default.
• W3144985489 hasConceptScore W3144985489C2779634585 @default.
• W3144985489 hasConceptScore W3144985489C2779889316 @default.
• W3144985489 hasConceptScore W3144985489C50965678 @default.
• W3144985489 hasConceptScore W3144985489C544519230 @default.
• W3144985489 hasConceptScore W3144985489C71924100 @default.
• W3144985489 hasIssue "5" @default.
• W3144985489 hasLocation W31449854891 @default.
• W3144985489 hasOpenAccess W3144985489 @default.
• W3144985489 hasPrimaryLocation W31449854891 @default.
• W3144985489 hasRelatedWork W1979737324 @default.
• W3144985489 hasRelatedWork W1986416180 @default.
• W3144985489 hasRelatedWork W1992385859 @default.
• W3144985489 hasRelatedWork W1994925135 @default.
• W3144985489 hasRelatedWork W2000995891 @default.
• W3144985489 hasRelatedWork W2063050628 @default.
• W3144985489 hasRelatedWork W2067108121 @default.
• W3144985489 hasRelatedWork W2076244388 @default.
• W3144985489 hasRelatedWork W3107045450 @default.
• W3144985489 hasRelatedWork W3144985489 @default.
• W3144985489 hasVolume "36" @default.
• W3144985489 isParatext "false" @default.
• W3144985489 isRetracted "false" @default.
• W3144985489 magId "3144985489" @default.
• W3144985489 workType "article" @default.