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- W3145013254 abstract "Aim: To investigate the toxic response in auditory cortex of guinea pigs caused by cis-platinum(DDP),and the protective role of melatonin in this effect.Methods: Cis-platinum and melatonin were injected peritoneally.LDH,MDA,NO in the auditory cortex were detected by spectrophotometer.Results: The body weight of the guinea pigs was diminished by peritoneal injection of Cis-platinum for 7 days(P0.01).Peritoneal injection of Cis-platinum induced the increased leakage of LDH(P0.05 vs injection of normal saline).This effect was reduced by injection of MT(P0.05).The content of MDA in the auditory cortex was also increased because of injection of Cis-platinumv for 7 days(P0.01) and MT reduced this effect(P0.05).The change of NO in the auditory cortex was not statistically significant after injection of Cis-platinum or Cis-platinum with MT.Conclusion: Peritoneal injection of Cis-platinum could destroy neurons in the auditory cortex.This effect could be reduced by melatonin by an anti-free radials mechanism." @default.
- W3145013254 created "2021-04-13" @default.
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- W3145013254 date "2009-01-01" @default.
- W3145013254 modified "2023-09-24" @default.
- W3145013254 title "THE PROTECTIVE EFFECT OF MELATONIN ON AUDITORY CORTEX TOXICITY INDUCED BY CIS-PLATINUM" @default.
- W3145013254 hasPublicationYear "2009" @default.
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