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• W3145048394 abstract "Introduction: Little is known about the well-being on long-term exposure to antiretroviral therapy. The ACTG Augmented Symptoms Distress Module (ASDM) is a validated tool which measures the presence of a total of 22 symptoms seen with HIV and quantifies the extent to which they cause distress to the patient. Methods: ELBE was a cross-sectional study that consecutively included adult HIV-infected patients presenting with viral suppression (B50 HIV RNA copies/mL) and ART exposure for at least five years. Patients were evaluated by four different questionnaires, including ASDM. Results: Of a total of 894 patients included in the three participating ELBE centres, complete data on ASDM were available for 698 patients (626 male, 69 female, 3 transsexual). Median age was 49.7 years (range, 23.3 82.5 years) and median exposure to ART was 11.5 years (range, 5 28 years). Median CD4 T-cell counts had increased from a CD4 nadir of 180 to currently 640 cells/ mL. Despite immunological and virological success, a high degree of symptom-related distress was noted in this patient population. In total, 63.8% and 36.3% of the patients had at least one ‘‘bothersome’’ or one ‘‘very bothersome’’ symptom, respectively. The symptoms most frequently reported to be ‘‘bothersome’’ or ‘‘very bothersome’’ were fatigue and energy loss (18.5% and 11.0% respectively), insomnia (12.8% and 11.6%), sadness and depression (13.0% and 10.0%), sexual dysfunction (12.0% and 10.0%), and changes in body appearance (11.0% and 10.9%). There was no association between the degree of symptom-related distress and gender, age or CD4 T-cell nadir. However, the history of AIDS-defining illnesses, comorbidities such as depression but also the duration of ART were significantly associated with a higher overall symptom summary score and with a higher frequency of symptoms. For example, in patients with at least 15 years of ART exposure, only 27.3% of the patients did not report at least one ‘‘bothersome’’ or ‘‘very bothersome’’ symptom. Conclusions: In this large group of positively selected HIV patients with virological success and long-term exposure to ART, a high degree of symptom-related distress was found. Medical care of HIV-infected patients should not only focus on optimal virological outcome. More data on quality of life in patients with long-term exposure to ART is needed." @default.
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• W3145048394 date "2014-01-01" @default.
• W3145048394 modified "2023-09-27" @default.
• W3145048394 title "Everything fine so far? Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy" @default.
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