Matches in SemOpenAlex for { <https://semopenalex.org/work/W3145062287> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W3145062287 abstract "Objective To study the role of hepatic sinusoidal endothelium injury during hepatic fibrogenesis induced by dimethylnitrosamine (DMN) in rats. Methods Hepatic fibrosis of rats was induced by administration of DMN intraperitoneally three times a week for 4 weeks. The animals were harvested on day 2 and week 1, 2, 3, 4, 5, 6, 8, 12, and 24. The formation of liver fibrosis and hepatic sinusoid capillarization were successively observed by morphological observation and other methods. Results Two days after treated with DMN, there was no obvious changes in the liver, but the fenestration of the sinusoidal endothelial cells decreased, and it became more obvious after one week. After four weeks, there was a large necrotic area and a number of pseudolobes appeared. The HA in the serum was lower than that of control (231.30 ng/ml+ 143.80 ng/ml vs 56.50 ng/ml+ 18.10 ng/ml; ?3.14, P0.05), but the hydroxyproline content was obviously higher than that of control (223.04 ug/g+37.09 ug/g vs 61.55 ug/g+20.85 ng/g; t=8.28, P0.05). Hepatic sinusoid capillarization was gradually formed and defenestration of the hepatic sinusoidal endothelium preceded the appearance of serious hepatocellular damage, hepatic fibrosis and basement membrane. Conclusions The damage and phenotypic alteration of the hepatic sinusoidal endothelium may be a vital issue triggering the liver fibrosis induced by DMN." @default.
- W3145062287 created "2021-04-13" @default.
- W3145062287 creator A5048182181 @default.
- W3145062287 date "2002-01-01" @default.
- W3145062287 modified "2023-10-17" @default.
- W3145062287 title "Role of hepatic sinusoidal endothelium injury in hepatic fibrogenesis induced by dimethylnitrosamine in rats" @default.
- W3145062287 hasPublicationYear "2002" @default.
- W3145062287 type Work @default.
- W3145062287 sameAs 3145062287 @default.
- W3145062287 citedByCount "0" @default.
- W3145062287 crossrefType "journal-article" @default.
- W3145062287 hasAuthorship W3145062287A5048182181 @default.
- W3145062287 hasConcept C126322002 @default.
- W3145062287 hasConcept C134018914 @default.
- W3145062287 hasConcept C142724271 @default.
- W3145062287 hasConcept C185592680 @default.
- W3145062287 hasConcept C2776193487 @default.
- W3145062287 hasConcept C2776417487 @default.
- W3145062287 hasConcept C2776992346 @default.
- W3145062287 hasConcept C2779797417 @default.
- W3145062287 hasConcept C2780559512 @default.
- W3145062287 hasConcept C2993667909 @default.
- W3145062287 hasConcept C71924100 @default.
- W3145062287 hasConceptScore W3145062287C126322002 @default.
- W3145062287 hasConceptScore W3145062287C134018914 @default.
- W3145062287 hasConceptScore W3145062287C142724271 @default.
- W3145062287 hasConceptScore W3145062287C185592680 @default.
- W3145062287 hasConceptScore W3145062287C2776193487 @default.
- W3145062287 hasConceptScore W3145062287C2776417487 @default.
- W3145062287 hasConceptScore W3145062287C2776992346 @default.
- W3145062287 hasConceptScore W3145062287C2779797417 @default.
- W3145062287 hasConceptScore W3145062287C2780559512 @default.
- W3145062287 hasConceptScore W3145062287C2993667909 @default.
- W3145062287 hasConceptScore W3145062287C71924100 @default.
- W3145062287 hasLocation W31450622871 @default.
- W3145062287 hasOpenAccess W3145062287 @default.
- W3145062287 hasPrimaryLocation W31450622871 @default.
- W3145062287 hasRelatedWork W1974036212 @default.
- W3145062287 hasRelatedWork W2074673802 @default.
- W3145062287 hasRelatedWork W2078036072 @default.
- W3145062287 hasRelatedWork W2123968402 @default.
- W3145062287 hasRelatedWork W2170053195 @default.
- W3145062287 hasRelatedWork W2349995152 @default.
- W3145062287 hasRelatedWork W2350627491 @default.
- W3145062287 hasRelatedWork W2351108972 @default.
- W3145062287 hasRelatedWork W2352826525 @default.
- W3145062287 hasRelatedWork W2360575506 @default.
- W3145062287 hasRelatedWork W2363785593 @default.
- W3145062287 hasRelatedWork W2366728761 @default.
- W3145062287 hasRelatedWork W2368992687 @default.
- W3145062287 hasRelatedWork W2370890630 @default.
- W3145062287 hasRelatedWork W2378743997 @default.
- W3145062287 hasRelatedWork W2386595854 @default.
- W3145062287 hasRelatedWork W2386611226 @default.
- W3145062287 hasRelatedWork W2958170735 @default.
- W3145062287 hasRelatedWork W3106838294 @default.
- W3145062287 hasRelatedWork W3147587099 @default.
- W3145062287 isParatext "false" @default.
- W3145062287 isRetracted "false" @default.
- W3145062287 magId "3145062287" @default.
- W3145062287 workType "article" @default.