FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3145086782> ?p ?o ?g. }

• W3145086782 abstract "Abstract Background The intimate relationship between coagulation and fibrinolysis in malignant tumors is a well-known phenomena, with the malignant phenotype enhancing coagulation and fibrinolysis. We hypothesized that soft tissue sarcoma (STS) affects the expression of coagulation and fibrinolysis markers, which could be used to distinguish STS from benign soft tissue tumors. We analyzed the correlations between plasma levels of D-dimer (DD), plasmin-α2 plasmin inhibitor complex (PIC), soluble fibrin (SF), and thrombin-antithrombin III complex (TAT) in benign soft tissue tumors and STS to elucidate whether these markers can be used to predict STS. Methods Plasma DD, PIC, SF and TAT levels in primary soft tissue tumors (benign 67, STS 68) were measured before biopsy or treatment. The marker levels were analyzed and compared to various clinicopathological parameters. Results In malignancy (STS), the average DD, PIC and SF levels were significantly higher than in benign tumors. Multivariate logistic analysis of continuous variables indicated that only PIC exhibited a significant difference (OR: 24.5, 95%CI: 3.55–170, p = 0.0012). Receiver operating characteristic curve analysis produced area under the curve values for DD: 0.691, PIC: 0.784, SF: 0.734 and TAT: 0.588. Youden’s index was used to establish thresholds of 0.37 (DD), 0.80 (PIC), 0.90 (SF) and 0.82 (TAT). Threshold values for PIC and SF indicated high specificity (0.881, 0.791) and high positive predictive value (0.818, 0.745), respectively. The highest accuracy value among the markers was observed for PIC (0.704). Significant differences in multivariate analysis of binary variables were demonstrated by categorizing low and high groups based on their threshold, PIC (≥0.80) (OR: 3.36, 95%CI: 1.19–9.43, p = 0.0212) and SF (≥0.90) (OR: 2.63, 95%CI: 1.04–6.66, p = 0.0404) . Conclusions Of the coagulation and fibrinolysis markers studied, increased PIC levels were related to STS and over 0.80 PIC was the most suitable for the prediction of STS, which, along with other diagnostic tools, represents a helpful subsidiary tool for the prediction of STS." @default.
• W3145086782 created "2021-04-13" @default.
• W3145086782 creator A5001153861 @default.
• W3145086782 creator A5002623356 @default.
• W3145086782 creator A5006823830 @default.
• W3145086782 creator A5009180170 @default.
• W3145086782 creator A5012087525 @default.
• W3145086782 creator A5015256294 @default.
• W3145086782 creator A5022969997 @default.
• W3145086782 creator A5042557807 @default.
• W3145086782 creator A5058766442 @default.
• W3145086782 creator A5075705962 @default.
• W3145086782 date "2021-04-07" @default.
• W3145086782 modified "2023-10-17" @default.
• W3145086782 title "Significance of coagulation and fibrinolysis markers for benign and malignant soft tissue tumors" @default.
• W3145086782 cites W1548036632 @default.
• W3145086782 cites W1990792747 @default.
• W3145086782 cites W2003487510 @default.
• W3145086782 cites W2015851846 @default.
• W3145086782 cites W2025531173 @default.
• W3145086782 cites W2025586500 @default.
• W3145086782 cites W2107436252 @default.
• W3145086782 cites W2119736160 @default.
• W3145086782 cites W2121960517 @default.
• W3145086782 cites W2125311110 @default.
• W3145086782 cites W2160060092 @default.
• W3145086782 cites W2295444208 @default.
• W3145086782 cites W2295559969 @default.
• W3145086782 cites W2324213097 @default.
• W3145086782 cites W2399822732 @default.
• W3145086782 cites W2616683876 @default.
• W3145086782 cites W2797672081 @default.
• W3145086782 cites W2988489630 @default.
• W3145086782 cites W2997471978 @default.
• W3145086782 cites W3006130785 @default.
• W3145086782 cites W4322694642 @default.
• W3145086782 doi "https://doi.org/10.1186/s12885-021-08091-1" @default.
• W3145086782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8028118" @default.
• W3145086782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33827473" @default.
• W3145086782 hasPublicationYear "2021" @default.
• W3145086782 type Work @default.
• W3145086782 sameAs 3145086782 @default.
• W3145086782 citedByCount "5" @default.
• W3145086782 countsByYear W31450867822022 @default.
• W3145086782 countsByYear W31450867822023 @default.
• W3145086782 crossrefType "journal-article" @default.
• W3145086782 hasAuthorship W3145086782A5001153861 @default.
• W3145086782 hasAuthorship W3145086782A5002623356 @default.
• W3145086782 hasAuthorship W3145086782A5006823830 @default.
• W3145086782 hasAuthorship W3145086782A5009180170 @default.
• W3145086782 hasAuthorship W3145086782A5012087525 @default.
• W3145086782 hasAuthorship W3145086782A5015256294 @default.
• W3145086782 hasAuthorship W3145086782A5022969997 @default.
• W3145086782 hasAuthorship W3145086782A5042557807 @default.
• W3145086782 hasAuthorship W3145086782A5058766442 @default.
• W3145086782 hasAuthorship W3145086782A5075705962 @default.
• W3145086782 hasBestOaLocation W31450867821 @default.
• W3145086782 hasConcept C126322002 @default.
• W3145086782 hasConcept C136948725 @default.
• W3145086782 hasConcept C142724271 @default.
• W3145086782 hasConcept C181199279 @default.
• W3145086782 hasConcept C185592680 @default.
• W3145086782 hasConcept C2776825266 @default.
• W3145086782 hasConcept C2778382381 @default.
• W3145086782 hasConcept C2778629024 @default.
• W3145086782 hasConcept C2779399171 @default.
• W3145086782 hasConcept C2779519742 @default.
• W3145086782 hasConcept C2781071845 @default.
• W3145086782 hasConcept C55493867 @default.
• W3145086782 hasConcept C58471807 @default.
• W3145086782 hasConcept C71924100 @default.
• W3145086782 hasConceptScore W3145086782C126322002 @default.
• W3145086782 hasConceptScore W3145086782C136948725 @default.
• W3145086782 hasConceptScore W3145086782C142724271 @default.
• W3145086782 hasConceptScore W3145086782C181199279 @default.
• W3145086782 hasConceptScore W3145086782C185592680 @default.
• W3145086782 hasConceptScore W3145086782C2776825266 @default.
• W3145086782 hasConceptScore W3145086782C2778382381 @default.
• W3145086782 hasConceptScore W3145086782C2778629024 @default.
• W3145086782 hasConceptScore W3145086782C2779399171 @default.
• W3145086782 hasConceptScore W3145086782C2779519742 @default.
• W3145086782 hasConceptScore W3145086782C2781071845 @default.
• W3145086782 hasConceptScore W3145086782C55493867 @default.
• W3145086782 hasConceptScore W3145086782C58471807 @default.
• W3145086782 hasConceptScore W3145086782C71924100 @default.
• W3145086782 hasIssue "1" @default.
• W3145086782 hasLocation W31450867821 @default.
• W3145086782 hasLocation W31450867822 @default.
• W3145086782 hasLocation W31450867823 @default.
• W3145086782 hasOpenAccess W3145086782 @default.
• W3145086782 hasPrimaryLocation W31450867821 @default.
• W3145086782 hasRelatedWork W1964793778 @default.
• W3145086782 hasRelatedWork W1992410460 @default.
• W3145086782 hasRelatedWork W1997021031 @default.
• W3145086782 hasRelatedWork W2033708906 @default.
• W3145086782 hasRelatedWork W2045679321 @default.
• W3145086782 hasRelatedWork W2084036015 @default.
• W3145086782 hasRelatedWork W2110172512 @default.
• W3145086782 hasRelatedWork W2415356478 @default.
• W3145086782 hasRelatedWork W2415576257 @default.

• next