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- W3145157067 abstract "This study was aimed to quantitatively detect the expression level of lysophosphatide acid acyltransferaseβ (lpaat β) mRNA in leukemia patients so as to provide theoretical basis for the target therapy of lpaatβ in leukemia. Real-time fluorescently quantitative PCR was used to detect the relative expression level of lpaatβ mRNA to analyze its expression change in various type of leukemia. The results showed that the lpaatβ mRNA expression level in acute leukemia (AL) patients was significantly higher than that in normal controls (p0.05); lpaatβ mRNA expression level in acute myeloid leukemia (AML) patients was significantly higher than that in normal controls (p0.05) and was positively correlated with white blood cell count (≥20.0×109/L) (p0.05) and CD34 expression level of leukemia,but was not related with extramedullary infiltration. Except for acute promyelocytic leukemia (APL), the lpaatβ mRNA expression level was negatively correlated with chemotherapy sensitivity in chronic myelaid leukemia (AML) patients. lpaatβ mRNA expression level in chronic myeloid leukemia (CML) patients was significantly higher than that in normal controls (p0.05). lpaatβ mRNA expression level in acute lymphoid leukemia (ALL) patients was not higher than that in normal controls (p0.05). It is concluded that the lpaatβ gene overexpression exists in both AML and CML patients. lpaat β produced by AML cells probably plays an important role in abnormal proliferation and drug-resistance of AML cells." @default.
- W3145157067 created "2021-04-13" @default.
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- W3145157067 date "2010-01-01" @default.
- W3145157067 modified "2023-09-22" @default.
- W3145157067 title "Lysophosphatidic Acid Acyltransferase β Gene Expression in Newly Diagnosed Leukemia Patients" @default.
- W3145157067 hasPublicationYear "2010" @default.
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