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- W3145168560 abstract "BACKGROUND OBJECTIVE: Endoglin is a marker of tumor angiogenesis. Increasing evidences proved that passive immunotherapy with anti-endoglin monoclonal antibody can effectively inhibit tumor growth, and xenogeneic homologous DNA vaccine can inhibit cross antitumor immunity. This study was to explore the inhibitory effect of a DNA vaccine encoding the extracellular domain of porcine endoglin (ppEDG) on tumor growth in a mouse colon carcinoma model. METHODS: ppEDG was used as a DNA vaccine to actively immunize the colon carcinoma-bearing mice. Tumor volume and survival rate of the mice were observed in 3-day intervals. Microvessel density (MVD) was detected by immunohistochemistry; antibodies against self-endoglin were detected by Western blot and ELISA; the B cells that secrete auto-antibodies against self-endoglin were detected by ELISPOT assay. RESULTS: Eighteen days after tumor cell inoculation, the tumor volume was significantly smaller in ppEDG-immunized group than in empty plasmid (e-p) group and normal saline (NS) group (P0.05), and the survival time was significantly longer in ppEDG-immunized group than in the control groups (P0.001). MVD was significantly lower in ppEDG-immunized group than in e-p group and NS group (19.2±4.5 vs. 76.9±14.4 and 81.4±16.9, P0.001). The antibodies against self-endoglin were identified in ppEDG-immunized group; the major subtypes were IgG1 and IgG2b. The auto-antibody-producing B cells were much more in ppEDG-immunized group than in e-p group and NS group (82.5±14.1 vs. 3.6±1.3 and 4.7±2.0, P0.001). CONCLUSION: ppEDG DNA vaccine could induce the production of auto-antibodies against self-endoglin, which further inhibit angiogenesis and growth of colon carcinoma." @default.
- W3145168560 created "2021-04-13" @default.
- W3145168560 creator A5038936819 @default.
- W3145168560 date "2005-01-01" @default.
- W3145168560 modified "2023-09-25" @default.
- W3145168560 title "A DNA Vaccine Encoding the Extracellular Domain of Porcine Endoglin Induces Antitumor Immunity in a Mouse Colon Carcinoma Model" @default.
- W3145168560 hasPublicationYear "2005" @default.
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