FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3145169823> ?p ?o ?g. }

• W3145169823 endingPage "107057" @default.
• W3145169823 startingPage "107057" @default.
• W3145169823 abstract "Idiopathic pulmonary fibrosis (IPF) is a disease that causes scarring and destruction of lung tissue that is ultimately fatal. There is a need to develop improved treatments for IPF. One problem with identifying novel treatments of IPF is the poor predictability of current preclinical models. Few model investigate lung function changes, rather relying on histological changes which doesn't adequately reflect the complete clinical situation. The aim of this study was to establish a novel model of pulmonary fibrosis where we could investigate changes in lung function, and histology. We have also utilised this model to investigate the role of platelets in pulmonary fibrosis as platelets have been recognised as having a broader role than just facilitating haemostasis. Lung fibrosis was induced in male C57BL6/J mice by intranasal bleomycin on Days 0, 1, 2, 5, 6 and 7. Platelets were depleted by twice-weekly administration of anti-platelet antibodies. On Day 35 mice were assessed by examining lung function, platelet infiltration into lung tissues and bronchoalveolar lavage fluid (BAL), levels of BAL Tissue growth factor (TGF)-β levels, and the degree of fibrosis evaluated histologically. Repeated bleomycin administration caused loss of lung function associated with fibrosis assessed histologically. Platelet depletion resulted in a reduction in fibrosis and modest inhibition of lung function changes. We have established a novel model of pulmonary fibrosis that is associated with a decline in lung function similar to the clinical setting. Furthermore, platelet depletion resulted in a less severe fibrosis suggesting that targeting platelets maybe worth further investigation." @default.
• W3145169823 created "2021-04-13" @default.
• W3145169823 creator A5029725332 @default.
• W3145169823 creator A5038983902 @default.
• W3145169823 creator A5068917260 @default.
• W3145169823 creator A5079387947 @default.
• W3145169823 creator A5085336912 @default.
• W3145169823 date "2021-05-01" @default.
• W3145169823 modified "2023-10-10" @default.
• W3145169823 title "A novel murine model of pulmonary fibrosis: the role of platelets in chronic changes induced by bleomycin" @default.
• W3145169823 cites W1707922975 @default.
• W3145169823 cites W1964199490 @default.
• W3145169823 cites W1973868069 @default.
• W3145169823 cites W1976547976 @default.
• W3145169823 cites W1998274991 @default.
• W3145169823 cites W2025029681 @default.
• W3145169823 cites W2051162734 @default.
• W3145169823 cites W2055609841 @default.
• W3145169823 cites W2057292199 @default.
• W3145169823 cites W2064307892 @default.
• W3145169823 cites W2075400164 @default.
• W3145169823 cites W2081045555 @default.
• W3145169823 cites W2085604666 @default.
• W3145169823 cites W2117488044 @default.
• W3145169823 cites W2150263858 @default.
• W3145169823 cites W2152974152 @default.
• W3145169823 cites W2164134225 @default.
• W3145169823 cites W252852947 @default.
• W3145169823 cites W2592017464 @default.
• W3145169823 cites W2600669583 @default.
• W3145169823 cites W2758834982 @default.
• W3145169823 cites W2788210393 @default.
• W3145169823 cites W2830998299 @default.
• W3145169823 cites W2898492718 @default.
• W3145169823 cites W2901041585 @default.
• W3145169823 cites W2911518936 @default.
• W3145169823 cites W2941685105 @default.
• W3145169823 cites W3085046828 @default.
• W3145169823 doi "https://doi.org/10.1016/j.vascn.2021.107057" @default.
• W3145169823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33819606" @default.
• W3145169823 hasPublicationYear "2021" @default.
• W3145169823 type Work @default.
• W3145169823 sameAs 3145169823 @default.
• W3145169823 citedByCount "9" @default.
• W3145169823 countsByYear W31451698232021 @default.
• W3145169823 countsByYear W31451698232022 @default.
• W3145169823 countsByYear W31451698232023 @default.
• W3145169823 crossrefType "journal-article" @default.
• W3145169823 hasAuthorship W3145169823A5029725332 @default.
• W3145169823 hasAuthorship W3145169823A5038983902 @default.
• W3145169823 hasAuthorship W3145169823A5068917260 @default.
• W3145169823 hasAuthorship W3145169823A5079387947 @default.
• W3145169823 hasAuthorship W3145169823A5085336912 @default.
• W3145169823 hasBestOaLocation W31451698232 @default.
• W3145169823 hasConcept C126322002 @default.
• W3145169823 hasConcept C142724271 @default.
• W3145169823 hasConcept C203014093 @default.
• W3145169823 hasConcept C2776232574 @default.
• W3145169823 hasConcept C2776694085 @default.
• W3145169823 hasConcept C2777714996 @default.
• W3145169823 hasConcept C2777961210 @default.
• W3145169823 hasConcept C2778341716 @default.
• W3145169823 hasConcept C2780559512 @default.
• W3145169823 hasConcept C2781244666 @default.
• W3145169823 hasConcept C71924100 @default.
• W3145169823 hasConcept C75603125 @default.
• W3145169823 hasConcept C89560881 @default.
• W3145169823 hasConceptScore W3145169823C126322002 @default.
• W3145169823 hasConceptScore W3145169823C142724271 @default.
• W3145169823 hasConceptScore W3145169823C203014093 @default.
• W3145169823 hasConceptScore W3145169823C2776232574 @default.
• W3145169823 hasConceptScore W3145169823C2776694085 @default.
• W3145169823 hasConceptScore W3145169823C2777714996 @default.
• W3145169823 hasConceptScore W3145169823C2777961210 @default.
• W3145169823 hasConceptScore W3145169823C2778341716 @default.
• W3145169823 hasConceptScore W3145169823C2780559512 @default.
• W3145169823 hasConceptScore W3145169823C2781244666 @default.
• W3145169823 hasConceptScore W3145169823C71924100 @default.
• W3145169823 hasConceptScore W3145169823C75603125 @default.
• W3145169823 hasConceptScore W3145169823C89560881 @default.
• W3145169823 hasLocation W31451698231 @default.
• W3145169823 hasLocation W31451698232 @default.
• W3145169823 hasOpenAccess W3145169823 @default.
• W3145169823 hasPrimaryLocation W31451698231 @default.
• W3145169823 hasRelatedWork W2102239057 @default.
• W3145169823 hasRelatedWork W2121729413 @default.
• W3145169823 hasRelatedWork W2364204753 @default.
• W3145169823 hasRelatedWork W2365811023 @default.
• W3145169823 hasRelatedWork W2380651012 @default.
• W3145169823 hasRelatedWork W2383309780 @default.
• W3145169823 hasRelatedWork W307228711 @default.
• W3145169823 hasRelatedWork W3147384383 @default.
• W3145169823 hasRelatedWork W3196482013 @default.
• W3145169823 hasRelatedWork W615981443 @default.
• W3145169823 hasVolume "109" @default.
• W3145169823 isParatext "false" @default.
• W3145169823 isRetracted "false" @default.
• W3145169823 magId "3145169823" @default.

• next