Matches in SemOpenAlex for { <https://semopenalex.org/work/W3145199229> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3145199229 abstract "Matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA) regulate proteol ysis of the extracellular matrix (ECM) and as a consequence are involved in a number of physiological and pathological states, including cancer. A crucial feature of cancer progression and metastasis is the disruption of the ECM and spreading of proliferating cancer cells. Over expression of MMPs and uPA is common for most types of cancers and correlates well with the adverse prognosis. Compounds able to modulate the activ ity of these proteolytic enzymes may become important agents in cancer therapy. In the present study, we examined the effect of the μ opioid receptor selective peptide, morphiceptin, and its two synthetic analogs on mRNA and protein levels of MMP 9 and uPA in three human cancer cell lines: MCF 7, HT 29, and SH SY5Y. Our findings indicate that in all three cell lines morphiceptin and its analogs attenuated MMP 9 expression and secretion and that this effect is not mediated by opioid receptors but is under control of the nitric oxide system. On the other hand, tested opioids up regulated uPA levels through a mechanism that involved opioid receptors. Different pathways by which opioid peptides exert their action in cancer cells can explain their contradictory influence on the level of cancer markers. DOI: 10.1134/S0026893312060052" @default.
- W3145199229 created "2021-04-13" @default.
- W3145199229 creator A5014008457 @default.
- W3145199229 date "2012-01-01" @default.
- W3145199229 modified "2023-09-27" @default.
- W3145199229 title "The Influence of Opioid Peptides on Matrix Metalloproteinase 9 and Urokinase Plasminogen Activator Expression in Three Cancer Cell Lines1" @default.
- W3145199229 cites W1493513500 @default.
- W3145199229 cites W1532948527 @default.
- W3145199229 cites W1565572133 @default.
- W3145199229 cites W1970614343 @default.
- W3145199229 cites W1971944129 @default.
- W3145199229 cites W1990646545 @default.
- W3145199229 cites W2012160376 @default.
- W3145199229 cites W2013298748 @default.
- W3145199229 cites W2016055585 @default.
- W3145199229 cites W2031247476 @default.
- W3145199229 cites W2042488510 @default.
- W3145199229 cites W2051491878 @default.
- W3145199229 cites W2055156670 @default.
- W3145199229 cites W2057895784 @default.
- W3145199229 cites W2059472881 @default.
- W3145199229 cites W2065791048 @default.
- W3145199229 cites W2085430724 @default.
- W3145199229 cites W2085954671 @default.
- W3145199229 cites W2087222252 @default.
- W3145199229 cites W2096537171 @default.
- W3145199229 cites W2124554874 @default.
- W3145199229 cites W2130135920 @default.
- W3145199229 cites W2152595481 @default.
- W3145199229 cites W2155231671 @default.
- W3145199229 cites W401157594 @default.
- W3145199229 hasPublicationYear "2012" @default.
- W3145199229 type Work @default.
- W3145199229 sameAs 3145199229 @default.
- W3145199229 citedByCount "0" @default.
- W3145199229 crossrefType "journal-article" @default.
- W3145199229 hasAuthorship W3145199229A5014008457 @default.
- W3145199229 hasConcept C109523444 @default.
- W3145199229 hasConcept C121608353 @default.
- W3145199229 hasConcept C126322002 @default.
- W3145199229 hasConcept C134018914 @default.
- W3145199229 hasConcept C170493617 @default.
- W3145199229 hasConcept C185592680 @default.
- W3145199229 hasConcept C189165786 @default.
- W3145199229 hasConcept C2779013556 @default.
- W3145199229 hasConcept C2779679481 @default.
- W3145199229 hasConcept C2781063702 @default.
- W3145199229 hasConcept C502942594 @default.
- W3145199229 hasConcept C55493867 @default.
- W3145199229 hasConcept C56219504 @default.
- W3145199229 hasConcept C71924100 @default.
- W3145199229 hasConcept C86803240 @default.
- W3145199229 hasConcept C88016717 @default.
- W3145199229 hasConcept C95444343 @default.
- W3145199229 hasConcept C96232424 @default.
- W3145199229 hasConceptScore W3145199229C109523444 @default.
- W3145199229 hasConceptScore W3145199229C121608353 @default.
- W3145199229 hasConceptScore W3145199229C126322002 @default.
- W3145199229 hasConceptScore W3145199229C134018914 @default.
- W3145199229 hasConceptScore W3145199229C170493617 @default.
- W3145199229 hasConceptScore W3145199229C185592680 @default.
- W3145199229 hasConceptScore W3145199229C189165786 @default.
- W3145199229 hasConceptScore W3145199229C2779013556 @default.
- W3145199229 hasConceptScore W3145199229C2779679481 @default.
- W3145199229 hasConceptScore W3145199229C2781063702 @default.
- W3145199229 hasConceptScore W3145199229C502942594 @default.
- W3145199229 hasConceptScore W3145199229C55493867 @default.
- W3145199229 hasConceptScore W3145199229C56219504 @default.
- W3145199229 hasConceptScore W3145199229C71924100 @default.
- W3145199229 hasConceptScore W3145199229C86803240 @default.
- W3145199229 hasConceptScore W3145199229C88016717 @default.
- W3145199229 hasConceptScore W3145199229C95444343 @default.
- W3145199229 hasConceptScore W3145199229C96232424 @default.
- W3145199229 hasLocation W31451992291 @default.
- W3145199229 hasOpenAccess W3145199229 @default.
- W3145199229 hasPrimaryLocation W31451992291 @default.
- W3145199229 hasRelatedWork W1419732335 @default.
- W3145199229 hasRelatedWork W1605302635 @default.
- W3145199229 hasRelatedWork W1971614181 @default.
- W3145199229 hasRelatedWork W1974783844 @default.
- W3145199229 hasRelatedWork W1991070447 @default.
- W3145199229 hasRelatedWork W1996862860 @default.
- W3145199229 hasRelatedWork W2026106944 @default.
- W3145199229 hasRelatedWork W2052133198 @default.
- W3145199229 hasRelatedWork W2061636999 @default.
- W3145199229 hasRelatedWork W2064180634 @default.
- W3145199229 hasRelatedWork W2068872058 @default.
- W3145199229 hasRelatedWork W2111043630 @default.
- W3145199229 hasRelatedWork W2144837057 @default.
- W3145199229 hasRelatedWork W2150026933 @default.
- W3145199229 hasRelatedWork W2151144083 @default.
- W3145199229 hasRelatedWork W2354991702 @default.
- W3145199229 hasRelatedWork W2740058080 @default.
- W3145199229 hasRelatedWork W2889956099 @default.
- W3145199229 hasRelatedWork W2068172096 @default.
- W3145199229 hasRelatedWork W2157842607 @default.
- W3145199229 isParatext "false" @default.
- W3145199229 isRetracted "false" @default.
- W3145199229 magId "3145199229" @default.
- W3145199229 workType "article" @default.