Matches in SemOpenAlex for { <https://semopenalex.org/work/W3145220688> ?p ?o ?g. }
- W3145220688 abstract "Abstract Background Malaria control in Kenya is based on case management and vector control using long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS). However, the development of insecticide resistance compromises the effectiveness of insecticide-based vector control programs. The use of pesticides for agricultural purposes has been implicated as one of the sources driving the selection of resistance. The current study was undertaken to assess the status and mechanism of insecticide resistance in malaria vectors in irrigated and non-irrigated areas with varying agrochemical use in western Kenya. Methods The study was carried out in 2018–2019 in Homa Bay County, western Kenya. The bioassay was performed on adults reared from larvae collected from irrigated and non-irrigated fields in order to assess the susceptibility of malaria vectors to different classes of insecticides following the standard WHO guidelines. Characterization of knockdown resistance ( kdr ) and acetylcholinesterase-inhibiting enzyme/angiotensin-converting enzyme ( Ace-1 ) mutations within Anopheles gambiae s.l. species was performed using the polymerase chain reaction (PCR) method. To determine the agricultural and public health insecticide usage pattern, a questionnaire was administered to farmers, households, and veterinary officers in the study area. Results Anopheles arabiensis was the predominant species in the irrigated (100%, n = 154) area and the dominant species in the non-irrigated areas (97.5%, n = 162), the rest being An. gambiae sensu stricto. In 2018, Anopheles arabiensis in the irrigated region were susceptible to all insecticides tested, while in the non-irrigated region reduced mortality was observed (84%) against deltamethrin. In 2019, phenotypic mortality was decreased (97.8–84% to 83.3–78.2%). In contrast, high mortality from malathion (100%), DDT (98.98%), and piperonyl butoxide (PBO)-deltamethrin (100%) was observed. Molecular analysis of the vectors from the irrigated and non-irrigated areas revealed low levels of leucine-serine/phenylalanine substitution at position 1014 (L1014S/L1014F), with mutation frequencies of 1–16%, and low-frequency mutation in the Ace-1 R gene (0.7%). In addition to very high coverage of LLINs impregnated with pyrethroids and IRS with organophosphate insecticides, pyrethroids were the predominant chemical class of pesticides used for crop and animal protection. Conclusion Anopheles arabiensis from irrigated areas showed increased phenotypic resistance, and the intensive use of pesticides for crop protection in this region may have contributed to the selection of resistance genes observed. The susceptibility of these malaria vectors to organophosphates and PBO synergists in pyrethroids offers a promising future for IRS and insecticide-treated net-based vector control interventions. These findings emphasize the need for integrated vector control strategies, with particular attention to agricultural practices to mitigate mosquito resistance to insecticides. Graphic abstract" @default.
- W3145220688 created "2021-04-13" @default.
- W3145220688 creator A5009139310 @default.
- W3145220688 creator A5017547441 @default.
- W3145220688 creator A5026874355 @default.
- W3145220688 creator A5031221050 @default.
- W3145220688 creator A5040602491 @default.
- W3145220688 creator A5047855563 @default.
- W3145220688 creator A5050734258 @default.
- W3145220688 creator A5054121392 @default.
- W3145220688 creator A5073047411 @default.
- W3145220688 creator A5076526197 @default.
- W3145220688 creator A5080216839 @default.
- W3145220688 creator A5080572760 @default.
- W3145220688 creator A5088736469 @default.
- W3145220688 date "2021-06-26" @default.
- W3145220688 modified "2023-10-16" @default.
- W3145220688 title "Insecticide resistance status of Anopheles arabiensis in irrigated and non-irrigated areas in western Kenya" @default.
- W3145220688 cites W1548082920 @default.
- W3145220688 cites W1553045567 @default.
- W3145220688 cites W1560024057 @default.
- W3145220688 cites W1572155692 @default.
- W3145220688 cites W1585349201 @default.
- W3145220688 cites W1815224447 @default.
- W3145220688 cites W1831100553 @default.
- W3145220688 cites W1919148717 @default.
- W3145220688 cites W1963189968 @default.
- W3145220688 cites W1979104664 @default.
- W3145220688 cites W1985117402 @default.
- W3145220688 cites W1986931855 @default.
- W3145220688 cites W1998139294 @default.
- W3145220688 cites W2000085399 @default.
- W3145220688 cites W2007288709 @default.
- W3145220688 cites W2014404765 @default.
- W3145220688 cites W2036272210 @default.
- W3145220688 cites W2049507704 @default.
- W3145220688 cites W2077998522 @default.
- W3145220688 cites W2079495259 @default.
- W3145220688 cites W2093030508 @default.
- W3145220688 cites W2095960451 @default.
- W3145220688 cites W2104103976 @default.
- W3145220688 cites W2105940695 @default.
- W3145220688 cites W2106675599 @default.
- W3145220688 cites W2111334238 @default.
- W3145220688 cites W2121626072 @default.
- W3145220688 cites W2130730638 @default.
- W3145220688 cites W2132784212 @default.
- W3145220688 cites W2145179914 @default.
- W3145220688 cites W2147222689 @default.
- W3145220688 cites W2149102265 @default.
- W3145220688 cites W2149369972 @default.
- W3145220688 cites W2152400766 @default.
- W3145220688 cites W2162209308 @default.
- W3145220688 cites W2162471183 @default.
- W3145220688 cites W2170798802 @default.
- W3145220688 cites W2179843350 @default.
- W3145220688 cites W2185898657 @default.
- W3145220688 cites W2188208204 @default.
- W3145220688 cites W2206123028 @default.
- W3145220688 cites W2211066155 @default.
- W3145220688 cites W2280129848 @default.
- W3145220688 cites W2296097999 @default.
- W3145220688 cites W2508406156 @default.
- W3145220688 cites W2559487843 @default.
- W3145220688 cites W2592155053 @default.
- W3145220688 cites W2729340437 @default.
- W3145220688 cites W2744065023 @default.
- W3145220688 cites W2767216810 @default.
- W3145220688 cites W2767302239 @default.
- W3145220688 cites W2792306882 @default.
- W3145220688 cites W2794280363 @default.
- W3145220688 cites W2809013757 @default.
- W3145220688 cites W2913230288 @default.
- W3145220688 cites W2964757705 @default.
- W3145220688 cites W2971303305 @default.
- W3145220688 cites W3045271285 @default.
- W3145220688 cites W3134597451 @default.
- W3145220688 cites W4240362325 @default.
- W3145220688 cites W57602146 @default.
- W3145220688 doi "https://doi.org/10.1186/s13071-021-04833-z" @default.
- W3145220688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8235622" @default.
- W3145220688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34174946" @default.
- W3145220688 hasPublicationYear "2021" @default.
- W3145220688 type Work @default.
- W3145220688 sameAs 3145220688 @default.
- W3145220688 citedByCount "17" @default.
- W3145220688 countsByYear W31452206882021 @default.
- W3145220688 countsByYear W31452206882022 @default.
- W3145220688 countsByYear W31452206882023 @default.
- W3145220688 crossrefType "journal-article" @default.
- W3145220688 hasAuthorship W3145220688A5009139310 @default.
- W3145220688 hasAuthorship W3145220688A5017547441 @default.
- W3145220688 hasAuthorship W3145220688A5026874355 @default.
- W3145220688 hasAuthorship W3145220688A5031221050 @default.
- W3145220688 hasAuthorship W3145220688A5040602491 @default.
- W3145220688 hasAuthorship W3145220688A5047855563 @default.
- W3145220688 hasAuthorship W3145220688A5050734258 @default.
- W3145220688 hasAuthorship W3145220688A5054121392 @default.
- W3145220688 hasAuthorship W3145220688A5073047411 @default.
- W3145220688 hasAuthorship W3145220688A5076526197 @default.