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• W3145315209 abstract "Argonaute (Ago) proteins have been demon- strated to be widely expressed and involved in post-tran- scriptional gene silencing and thus play key roles in carcinogenesis. Nevertheless, little is known about the specific role of Ago2 in gastric cancer (GC). Thus, we aimed to study the expression of Ago2 in 363 primary GC, 8 corresponding lymph node metastases and 10 non-neo- plastic surrounding gastric epithelium tissues by immuno- histochemical analyses and tissue microarray. The expression of Ago2 was also correlated with clinicopath- ological characteristics and HER-2 status. Ago2 expression levels in primary GC and corresponding lymph node metastases were significantly higher compared with heal- thy controls (P 0.05). But, there was no difference of Ago2 between GC and its metastatic lymph node (P ( 0.05). Ago2 up-regulation had no correlation with GC patients' age, tumor location, tumor size, gross morphology or tumor infiltration. However, we found that Ago2 was different between HER-2 positive and HER-2 negative groups (P = 0.044), which had been demonstrated to be related to GC prognosis. And there was a great correlation between Ago2 expression and the tumor differentiation (P = 0.007), lymph node invasion (P = 0.000) and clini- cal stage (P = 0.006). Interestingly, Ago2 was also cor- related to patients' gender (P = 0.004), which may suggest a possible role of hormonal signal in the mechanisms of Ago2. Thus, our results suggested that up-regulation of Ago2 may play an important role in GC carcinogenesis and progression. Further studies on the cellular functions of Ago2 need to address these issues." @default.
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• W3145315209 date "2013-01-01" @default.
• W3145315209 modified "2023-09-26" @default.
• W3145315209 title "Up-regulation of Ago2 expression in gastric carcinoma" @default.
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