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- W3145320672 abstract "Aim:To clarify the cause of poor oral absorption of ginsenoside Rg_1(Rg_1),the active ingredient in Panax notoginseng saponins(PNS)used for treating hemorrhage.Methods:Caco-2 cell monolayers were used as an in vitro model to study the transport mechanism of Rg_1 across the intestinal mucosa.Moreover, the serum concentration-time profiles after peroral(po),intraduodenal(id),portal venous(pv)and tail venous(iv)administration of Rg_1 in rats were compared to evaluate the first-pass effects in the stomach,intestine,and liver.Results:Up- take of Rg_1 by Caco-2 cell monolayers was temperature-dependent,but was not influenced by cyclosporin A.The change in the apical pH produced no obvious effect on the uptake of Rg_1.The uptake and transport of Rg_1 was non-saturable; whereas the flux from the apical compartment to the basolateral compartment(A- B)increased in a linear manner with the increase in concentration,indicating passive transport.An apparent permeability coefficient of(2.59±0.17)×10~(-7) cm/s (C_0=1 mg/mL)predicted incomplete absorption.A significant difference was ob- served between the po(F_(po) was 3.29% at a dose of 1500 mg/kg),id(F_(id) was 6.60% at a dose of 1200 mg/kg)and pv(F_(pv) was 50.56%)administration methods,and the barrier function of the intestine was more significant than those of the stomach and liver in the absorption process.Conclusion:Elimination in the stomach,large intestine and liver contributed to the low oral bioavailability of Rg_1,but low mem- brane permeability might be a more important factor in determining the extent of absorption." @default.
- W3145320672 created "2021-04-13" @default.
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- W3145320672 date "2006-01-01" @default.
- W3145320672 modified "2023-09-24" @default.
- W3145320672 title "Difference in oral absorption of ginsenoside Rg_1 between in vitro and in vivo models" @default.
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