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• W3145367004 abstract "The impact of a challenge with moderately pathogenic <em>Escherichia coli</em> O128:C6 on the digestive physiology and gut bacterial community of growing rabbits under two feeding programmes was analysed. Upon weaning (28 d old), 180 rabbits were allocated to four groups (9 cages of 5 rabbits per group) for two weeks: group C100 was non-inoculated and fed <em>ad libitum</em>; C70 was non-inoculated and feed intake was limited to 70% of C100; I100 and I70 were inoculated and fed <em>ad libitum</em> or restricted to 70%, respectively. At the age of 31 d (D0), rabbits were orally inoculated with <em>E. coli</em> (2.2×108 colony forming units/rabbit). The effects of inoculation spiked on D4, with a 28% lower growth rate for I100 than for C100. Limited feed intake reinforced the inoculation’s effects on growth: I70 had a 66% lower growth rate than C70. The morbidity rate peaked at 42% between D4 and D7 for inoculated groups, without significant effect of the feed intake level. <em>E. coli</em> concentration peaked on D5/D6 in the caecum of the I100 and I70 groups. Inoculation reduced by 30% (<em>P</em>&lt;0.05) the villus height/crypt depth and villus/crypt area ratios in the ileum, with no significant effect of the intake level. Inoculation was associated with a tenfold increase in serum haptoglobin (<em>P</em>&lt;0.001) for both <em>ad libitum</em> and restricted rabbits. On D5, the inoculation modified the structure of the ileal bacterial community (<em>P</em>&lt;0.05), but not that of the caecum. The feed intake level did not affect either the structure or diversity of the bacterial community, both in the ileum and caecum." @default.
• W3145367004 created "2021-04-13" @default.
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• W3145367004 date "2021-03-31" @default.
• W3145367004 modified "2023-09-30" @default.
• W3145367004 title "Challenging the growing rabbit with a moderately pathogenic E. coli under ad libitum or limited feed intake conditions: impact on digestive physiology, bacterial communities, and on post-weaning growth" @default.
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• W3145367004 doi "https://doi.org/10.4995/wrs.2021.14089" @default.
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