FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3145411634> ?p ?o ?g. }

• W3145411634 endingPage "323" @default.
• W3145411634 startingPage "309" @default.
• W3145411634 abstract "Polypropylene (PP) mesh is widely used to reinforce tissues. The foreign body reaction (FBR) to the implant is dominated by innate immune cells, especially macrophages. However, considerable numbers of adaptive immune cells, namely T cells, have also been regularly observed, which appear to play a crucial role in the long-term host response.This study investigated the FBR to seven human PP meshes, which were removed from the abdomen for recurrence after a median of one year. Using immunofluorescence microscopy, the FBR was examined for various innate (CD11b+ myeloid, CD68+ macrophages, CD56+ NK) and adaptive immune cells (CD3+ T, CD4+ T-helper, CD8+ cytotoxic, FoxP3+ T-regulatory, CD20+ B) as well as conventional immune cells (defined as cells expressing their specific immune cell marker without co-expressing CD68).T-helper cells (19%) and regulatory T-cells (25%) were present at comparable rates to macrophages, and clustered significantly toward the mesh fibers. For all cell types the lowest proportions of conventional cells (< 60%) were observed at the mesh-tissue interface, but increased considerably at about 50-100 µm, indicating reduced stimulation with rising distance to the mesh fibers.Both innate and adaptive immune cells participate in the chronic FBR to PP meshes with T cells and macrophages being the predominant cell types, respectively. In concordance with the previous data, many cells presented a hybrid pattern near the mesh fibers. The complexity of the immune reaction seen within the foreign body granuloma may explain why approaches focusing on specific cell types have not been very successful in reducing the chronic FBR." @default.
• W3145411634 created "2021-04-13" @default.
• W3145411634 creator A5016687099 @default.
• W3145411634 creator A5030034267 @default.
• W3145411634 creator A5068577073 @default.
• W3145411634 creator A5068945585 @default.
• W3145411634 date "2021-03-31" @default.
• W3145411634 modified "2023-10-01" @default.
• W3145411634 title "Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen" @default.
• W3145411634 cites W1428861419 @default.
• W3145411634 cites W1567036161 @default.
• W3145411634 cites W1747617663 @default.
• W3145411634 cites W1904280223 @default.
• W3145411634 cites W1972812377 @default.
• W3145411634 cites W1988789473 @default.
• W3145411634 cites W1994444383 @default.
• W3145411634 cites W1995063875 @default.
• W3145411634 cites W2000868542 @default.
• W3145411634 cites W2001024793 @default.
• W3145411634 cites W2004855073 @default.
• W3145411634 cites W2006196877 @default.
• W3145411634 cites W2015844387 @default.
• W3145411634 cites W2033820276 @default.
• W3145411634 cites W2046188218 @default.
• W3145411634 cites W2054472394 @default.
• W3145411634 cites W2064815887 @default.
• W3145411634 cites W2065930754 @default.
• W3145411634 cites W2075271267 @default.
• W3145411634 cites W2079462136 @default.
• W3145411634 cites W2111379047 @default.
• W3145411634 cites W2117949894 @default.
• W3145411634 cites W2122561878 @default.
• W3145411634 cites W2125631056 @default.
• W3145411634 cites W2134400362 @default.
• W3145411634 cites W2137259894 @default.
• W3145411634 cites W2143954489 @default.
• W3145411634 cites W2163175900 @default.
• W3145411634 cites W2294876293 @default.
• W3145411634 cites W2324544461 @default.
• W3145411634 cites W2340208513 @default.
• W3145411634 cites W2588641015 @default.
• W3145411634 cites W2593962829 @default.
• W3145411634 cites W2737860676 @default.
• W3145411634 cites W2740495409 @default.
• W3145411634 cites W2778575734 @default.
• W3145411634 cites W2786811086 @default.
• W3145411634 cites W2799932713 @default.
• W3145411634 cites W2884295001 @default.
• W3145411634 cites W2899956132 @default.
• W3145411634 cites W2910765752 @default.
• W3145411634 cites W2911543518 @default.
• W3145411634 cites W2918534723 @default.
• W3145411634 cites W2923819818 @default.
• W3145411634 cites W2963774220 @default.
• W3145411634 cites W2969912154 @default.
• W3145411634 cites W2988757162 @default.
• W3145411634 cites W2999794673 @default.
• W3145411634 cites W3028488454 @default.
• W3145411634 cites W3028679994 @default.
• W3145411634 cites W3047216790 @default.
• W3145411634 cites W3092038809 @default.
• W3145411634 cites W4211150982 @default.
• W3145411634 doi "https://doi.org/10.1007/s10029-021-02396-7" @default.
• W3145411634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33788008" @default.
• W3145411634 hasPublicationYear "2021" @default.
• W3145411634 type Work @default.
• W3145411634 sameAs 3145411634 @default.
• W3145411634 citedByCount "10" @default.
• W3145411634 countsByYear W31454116342022 @default.
• W3145411634 countsByYear W31454116342023 @default.
• W3145411634 crossrefType "journal-article" @default.
• W3145411634 hasAuthorship W3145411634A5016687099 @default.
• W3145411634 hasAuthorship W3145411634A5030034267 @default.
• W3145411634 hasAuthorship W3145411634A5068577073 @default.
• W3145411634 hasAuthorship W3145411634A5068945585 @default.
• W3145411634 hasBestOaLocation W31454116341 @default.
• W3145411634 hasConcept C136449434 @default.
• W3145411634 hasConcept C154317977 @default.
• W3145411634 hasConcept C157081693 @default.
• W3145411634 hasConcept C167672396 @default.
• W3145411634 hasConcept C193419808 @default.
• W3145411634 hasConcept C202751555 @default.
• W3145411634 hasConcept C203014093 @default.
• W3145411634 hasConcept C2776090121 @default.
• W3145411634 hasConcept C2779727006 @default.
• W3145411634 hasConcept C47742525 @default.
• W3145411634 hasConcept C55493867 @default.
• W3145411634 hasConcept C67662055 @default.
• W3145411634 hasConcept C86803240 @default.
• W3145411634 hasConcept C8891405 @default.
• W3145411634 hasConcept C95444343 @default.
• W3145411634 hasConceptScore W3145411634C136449434 @default.
• W3145411634 hasConceptScore W3145411634C154317977 @default.
• W3145411634 hasConceptScore W3145411634C157081693 @default.
• W3145411634 hasConceptScore W3145411634C167672396 @default.
• W3145411634 hasConceptScore W3145411634C193419808 @default.
• W3145411634 hasConceptScore W3145411634C202751555 @default.
• W3145411634 hasConceptScore W3145411634C203014093 @default.

• next