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- W3145492046 abstract "AIM:Alkaloid(AF),essential oil(EOF),flavonoid(FF),saponin(SF) and polysaccharide(PF) fractions obtained from Oxytropis falcata Bunge were investigated for their anti-inflammatory and antioxidant activities in vivo and in vitro for the first time.METHOD:Two anti-inflammatory animal models(TPA-and carrageenin-induced) and three antioxidant models(total antioxidant activity,DPPH and hydroxyl radical-scavenging activity) were employed to evaluate the anti-inflammatory and antioxidant activities of O.falcata fractions.Animal models of acute inflammation and subacute inflammation were adopted to probe the possible anti-inflammatory mechanism.RESULTS:Flavonoids were major active constituents responsible for the anti-inflammatory and antioxidant activities of O.falcata.The anti-inflammatory mechanism of FF may be due,at least in part,to the inhibition of PGE2 levels,decrease of MDA levels and enhancement of SOD,CAT and GSH-Px activities without inducing any gastric damage.CONCLUSION:The results provide evidence to support the folk medicinal utilization of O.falcata for the treatment of inflammation." @default.
- W3145492046 created "2021-04-13" @default.
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- W3145492046 date "2010-01-01" @default.
- W3145492046 modified "2023-09-24" @default.
- W3145492046 title "Anti-inflammatory and Antioxidant Activities of Oxytropis falcata Fractions and Its Possible Anti-inflammatory Mechanism" @default.
- W3145492046 hasPublicationYear "2010" @default.
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