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- W3145526685 abstract "Objective To investigate the relationship between single nucleotide polymorphism (SNP) of Vitamin D receptor (VDR) gene start codon and the prostate cancer.Methoda Two groups of subjects were included.60 patients with prostate cancer and 50 patients with benign prostate hyperplasia were examined respectively.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used in determining VDR genotyper.The relationship was evaluated between VDR gene poly-morphism of Fok I alleles and prostate cancer.Results The distribution of genotypes and alleles had significant difference between prostate cancer and BPH (P<0.05).The distribution of genotypes had significant difference between the high-risk group and the low-risk group of prostate cancer (P<0.05).Conclii-sions VDR Fok I start codon alleles polymorphisms may be correlated with prostate cancer,and may be a hood marker for prostate cancer.Key words: Prostate cancer; Start codon; Vitamin D receptor; Single nucleotide polymorphism" @default.
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- W3145526685 date "2009-12-01" @default.
- W3145526685 modified "2023-09-24" @default.
- W3145526685 title "Relationship between snp of vitamin d receptor start codon and prostate cancer" @default.
- W3145526685 doi "https://doi.org/10.3760/cma.j.issn.1007-1245.2009.23.004" @default.
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