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• W3145557360 abstract "As a ubiquitous and highly persistent environ- mental contaminant, the clear mechanisms to explain any perfluorooctanesulfonate (PFOS)-induced immunotoxicity are still unknown. This study here sought to examine the ability of PFOS to potentially perturb T-helper (TH)-1 and TH-2 cell cytokine secreting activities, as well as to cause shifts in antibody isotype levels, and possible mechanisms involved in PFOS-induced immunotoxicity. Adult male C57BL/6 mice were exposed to PFOS daily via gavage for 60 days (0, 0.5, 1, 5, 25, or 50 mg/kg total administered dose (TAD)). One day after the final exposure, the ex vivo production of the TH1-type cytokines (IL-2 and IFN-c), TH2-type (IL-4), and IL-10 cytokines by isolated spleno- cytes, serum levels of immunoglobulin (Ig) were assessed via ELISA or ELISPOT. The results showed that IL-4 secretion was increased at exposure C5 mg PFOS/kg TAD in a dose-dependent manner. PFOS exposure increased IL-10 but decreased IL-2 and IFN-c formation markedly at 50 mg PFOS/kg TAD. Serum levels of sheep red blood cells (SRBC)-specific IgM synthesis decreased signifi- cantly with PFOS exposure in a dose-related manner; serum SRBC-specific IgG, IgG1, and IgE levels increased with 50 mg PFOS/kg TAD regimens. These results indi- cated that, after a long-term exposure to PFOS, a host's immune state is likely to be characterized by a shift toward a more TH2-like state that, in turn, may lead to enhance- ment of their humoral response and suppression of their cellular response at levels of upper range for occupation- ally exposed workers or approximately 150-fold for general human population." @default.
• W3145557360 created "2021-04-13" @default.
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• W3145557360 date "2011-01-01" @default.
• W3145557360 modified "2023-09-27" @default.
• W3145557360 title "Sub-chronic effect of perfluorooctanesulfonate (PFOS) on the balance of type 1 and type 2 cytokine in adult C57BL6 mice" @default.
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