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- W3145576110 abstract "Objective:To study the serum level of vitamin A and changes of immune function in children with recurrent respiratory tract infection,explore the feasibility of vitamin A as an immune adjuvant in improving immune function of children.Methods:60 children with recurrent respiratory tract infection were selected as experimental group,20 children were selected as control group,their ages were from 6 months to 3 years;the children in experimental group were divided into A group and B group randomly,the children in A group were treated with conventional dose vitamin A,while B group was control observation group;the serum levels of vitamin A in experimental group and control group were detected by micro-fluorescence method;the blood lymphocyte subtypes(CD3+,CD3+CD4+,CD3+CD8+,CD4+/CD8+),immunoglobulins(IgG,IgA,IgM) and C3 were detected by flow cytometry and immune transmission turbidimetric method.Results:The serum level of vitamin A in experimental group was significantly lower than that in control group(P0.05),and the amounts of blood lymphocyte subtypes(except CD8+) and immunoglobulins(except IgM) in experimental group were significantly lower than those in control group;the serum level of vitamin A in vitamin A supplement group was significantly higher than that in non-vitamin A supplement group,the amounts of blood lymphocyte subtypes(except CD3+CD8+) in vitamin A supplement group were significantly higher than those in non-vitamin A supplement group;there was positive correlation between serum level of vitamin A and CD3+,CD3+CD4+,CD4+/CD8+,IgA,there was negative correlation between serum level of vitamin A and CD3+CD8+,but there was no correlation between serum level of vitamin A and IgG,IgM,C3.Conclusion:The serum level of vitamin A and immune function decrease significantly in children with recurrent respiratory tract infection,after supplement of vitamin A,the indexes of immune function increase with the increase of serum vitamin A level;vitamin A can be used as an immune adjuvant in improving immune function of children,vitamin A should be supplied according to conventional dose of vitamin A deficiency." @default.
- W3145576110 created "2021-04-13" @default.
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- W3145576110 date "2010-01-01" @default.
- W3145576110 modified "2023-09-25" @default.
- W3145576110 title "Clinical investigation on application of vitamin A as an immune adjuvant in improving immune function of children" @default.
- W3145576110 hasPublicationYear "2010" @default.
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