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- W3145655305 abstract "瞄准：调查 endothelin 希腊语字母的第七字受体阻滞物是否在在长期的心力衰竭(CHF ) 的一个高血压的老鼠模型的心脏的改变和幸存上提供类似的利益。方法：男性击容易自发地， hypertensive (SHR-SP ) 老鼠受到左冠的动脉的永久结扎并且与 endothelin 希腊语字母的第七字受体阻滞物 LU 135252 被对待 6 个星期(30 mg.kg (在结扎或 untreatment 以后开始 24 h 的 -1).d(-1)) 。假冒操作老鼠用作正常控制。吝啬的动脉的血压(地图)，心搏率( HR )，左室的结束心脏舒张的压力( LVEDP )，左室的收缩性( LV dp/dt (最大))，左室的内部直径( LVD )和圆周( LVC )，氏族的厚度，左室的空隙的骨胶原内容(国际计算中心)和心重量( HW )在处理的结束被测量。结果：与未经治疗的组相比， LU 135252 趋于增加 HW (1.43 +/-0.03 对 1.38 +/-0.04 g；P> 0.05 ) ，增加的 LVD (7.65+/-0.24 公里对 6.58+/-0.14 公里；P 0.05 ) ，减少的 LVEDP (14 4 毫米汞柱对 27+/-4 毫米汞柱；P<0.05 ) 并且改进 LV dp/dtmax (4230+/-450 mmHg/s 对 1950+/-400 mmHg/s；P<0.05 ) ；幸存没显著地被延长(13% 对 11% ；P=NS ) 。结论：在 CHF 的这个高血压的老鼠模型，然而，有 LU 135252 的长期的 endothelin 希腊语字母的第七字受体封锁改进心脏的血液动力学它不影响长期的幸存并且变得更坏心脏的改变。因此， endothelin 希腊语字母的第七字受体对手是不大可能的与 CHF 在病人的管理有一个重要角色。" @default.
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- W3145655305 date "2006-01-01" @default.
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- W3145655305 title "Effects of endothelin ETA receptor blocker LU 135252 on cardiac remodeling and survival in a hypertensive rat model of chronic heart failure" @default.
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