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- W3145657995 abstract "P-selectin glycoprotein ligand-1 (PSGL-1 ) 不仅作为一个锚分子工作由它和 P-selectin 的相互作用在 ischemic 织物捕获单核白血球和另外的白血球到 endothelial 房间，而且 transduces 发信号开始坚挺的粘附。Endothelial 祖先房间从单核白血球被导出并且在 neovascularization 起一个很重要的作用。endothelial 祖先房间的移植是有希望的治疗学的策略改进象心肌、服的梗塞那样的 ischemic 疾病的治疗；然而，它的功效现在被很少移植房间在 ischemic 织物遵守并且积累的事实限制。在这研究，我们试图调查 PSGL-1 基因的 overexpression 是否支持 endothelial 祖先房间粘附活动并且探索内在的机制。我们发现在有人的 PSGL-1 基因的 transfection 以后， endothelial 祖先房间展出了更高的亲密关系到激活的人的脐的静脉 endothelial 房间或重新结合的 P-selectin/ICAM-1 单层。endothelial 祖先房间表面上的 PSGL-1-enhanced 2-integrin 表示的 overexpression，和这效果是 Syk 依赖者。特定的 Syk 禁止者在表面 2-integrin 表示和 endothelial 祖先房间的粘合剂亲密关系上废除了 PSGL-1 的 overexpression 的提高的效果。这些结果建议 Syk 在 endothelial 祖先房间 PSGL-1 下游地在信号 transduction 起一个关键作用，并且 PSGL-1 的 overexpression 通过 Syk 的提高的激活和后面的 integrin 激活改进 endothelial 祖先房间粘合剂性质。" @default.
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- W3145657995 date "2010-01-01" @default.
- W3145657995 modified "2023-09-26" @default.
- W3145657995 title "Overexpression of P-selectin glycoprotein ligand-1 enhances adhesive properties of endothelial progenitor cells through Syk activation" @default.
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