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- W3145658294 abstract "For the development of new ligands as potential imaging agents for the serotonin transporter (SERT),a series of diphenyl ether derivatives have been synthesized,characterized,and evaluated for their in vitro binding affinities to the SERT. Among the above compounds,2-(2-((dimethylamino)methyl)-4-fluoro-phenoxy)-5-bromobenzenamine (15) and 2-(2-((dimethylamino)methyl)-4-fluorophenoxy)-5-iodobenzene amine (16) show high binding affinities for the SERT with Ki values of 0.28 and 0.20 nmol·L-1,respectively. They can be further labeled with carbon-11,fluorine-18,iodine-123 or bromine-76,and evaluated as useful imaging agents for the SERT. Moreover,the study of the structure-activity relationship (SAR) provides some useful information for the future design of new ligands." @default.
- W3145658294 created "2021-04-13" @default.
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- W3145658294 date "2008-01-01" @default.
- W3145658294 modified "2023-09-25" @default.
- W3145658294 title "Synthesis and in vitro evaluation of new diphenyl ether derivatives as serotonin transporter ligands" @default.
- W3145658294 hasPublicationYear "2008" @default.
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