FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3145745909> ?p ?o ?g. }

• W3145745909 abstract "Abstract The high degree of morbidity and mortality in colorectal cancer (CRC) patients is largely due to the development of chemoresistance against conventional chemotherapeutic drugs. In view of the accumulating evidence that various dietary botanicals offer a safe, inexpensive and multi-targeted treatment option, herein, we hypothesized that a combination of Andrographis paniculata and Oligomeric Proanthocyanidins (OPCs) might interact together with regard to anti-tumorigenic activity in CRC. As a result, we demonstrated the enhanced anti-cancer activity between these two botanical extracts in terms of their ability to inhibit cancer cell growth, suppress colony formation and induce apoptosis. Furthermore, we validated these findings in subcutaneous xenograft model and in patient derived primary epithelial 3D organoids. Transcriptomic profiling identified involvement of metabolic pathways and ferroptosis-associated genes, including HMOX1, GCLC and GCLM, that may be responsible for the increased anti-tumorigenic activity by the two compounds. Collectively, our study provides novel evidence in support of the combinatorial use of andrographis and OPCs as a potential therapeutic option, perhaps as an adjunctive treatment to classical drugs, in patients with colorectal cancer." @default.
• W3145745909 created "2021-04-13" @default.
• W3145745909 creator A5019440060 @default.
• W3145745909 creator A5019939654 @default.
• W3145745909 creator A5051727905 @default.
• W3145745909 creator A5058068325 @default.
• W3145745909 creator A5063185047 @default.
• W3145745909 date "2021-04-06" @default.
• W3145745909 modified "2023-10-17" @default.
• W3145745909 title "Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer" @default.
• W3145745909 cites W1741548448 @default.
• W3145745909 cites W1924762808 @default.
• W3145745909 cites W1972179974 @default.
• W3145745909 cites W1991131105 @default.
• W3145745909 cites W1995121097 @default.
• W3145745909 cites W2013885508 @default.
• W3145745909 cites W2056468898 @default.
• W3145745909 cites W2071959081 @default.
• W3145745909 cites W2074596479 @default.
• W3145745909 cites W2080980430 @default.
• W3145745909 cites W2087929997 @default.
• W3145745909 cites W2096439168 @default.
• W3145745909 cites W2102614122 @default.
• W3145745909 cites W2114682337 @default.
• W3145745909 cites W2116731538 @default.
• W3145745909 cites W2119903726 @default.
• W3145745909 cites W2121153992 @default.
• W3145745909 cites W2121836743 @default.
• W3145745909 cites W2123431502 @default.
• W3145745909 cites W2136787567 @default.
• W3145745909 cites W2149031002 @default.
• W3145745909 cites W2155582899 @default.
• W3145745909 cites W2161531885 @default.
• W3145745909 cites W2162313061 @default.
• W3145745909 cites W2180777157 @default.
• W3145745909 cites W2256742438 @default.
• W3145745909 cites W2347003476 @default.
• W3145745909 cites W2528617225 @default.
• W3145745909 cites W2560375214 @default.
• W3145745909 cites W2615483558 @default.
• W3145745909 cites W2737373628 @default.
• W3145745909 cites W2753950393 @default.
• W3145745909 cites W2762087180 @default.
• W3145745909 cites W2770469636 @default.
• W3145745909 cites W2775507468 @default.
• W3145745909 cites W2781525129 @default.
• W3145745909 cites W2791177186 @default.
• W3145745909 cites W2793573608 @default.
• W3145745909 cites W2797819071 @default.
• W3145745909 cites W2801324082 @default.
• W3145745909 cites W2802665478 @default.
• W3145745909 cites W2806572083 @default.
• W3145745909 cites W2807520746 @default.
• W3145745909 cites W2890096979 @default.
• W3145745909 cites W2907792329 @default.
• W3145745909 cites W2939543377 @default.
• W3145745909 cites W3081284759 @default.
• W3145745909 doi "https://doi.org/10.1038/s41598-021-87283-y" @default.
• W3145745909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8024269" @default.
• W3145745909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33824419" @default.
• W3145745909 hasPublicationYear "2021" @default.
• W3145745909 type Work @default.
• W3145745909 sameAs 3145745909 @default.
• W3145745909 citedByCount "29" @default.
• W3145745909 countsByYear W31457459092021 @default.
• W3145745909 countsByYear W31457459092022 @default.
• W3145745909 countsByYear W31457459092023 @default.
• W3145745909 crossrefType "journal-article" @default.
• W3145745909 hasAuthorship W3145745909A5019440060 @default.
• W3145745909 hasAuthorship W3145745909A5019939654 @default.
• W3145745909 hasAuthorship W3145745909A5051727905 @default.
• W3145745909 hasAuthorship W3145745909A5058068325 @default.
• W3145745909 hasAuthorship W3145745909A5063185047 @default.
• W3145745909 hasBestOaLocation W31457459091 @default.
• W3145745909 hasConcept C104317684 @default.
• W3145745909 hasConcept C121608353 @default.
• W3145745909 hasConcept C126322002 @default.
• W3145745909 hasConcept C127561419 @default.
• W3145745909 hasConcept C142724271 @default.
• W3145745909 hasConcept C150194340 @default.
• W3145745909 hasConcept C162317418 @default.
• W3145745909 hasConcept C190283241 @default.
• W3145745909 hasConcept C204787440 @default.
• W3145745909 hasConcept C2777970627 @default.
• W3145745909 hasConcept C2779881523 @default.
• W3145745909 hasConcept C2781173740 @default.
• W3145745909 hasConcept C2781357234 @default.
• W3145745909 hasConcept C502942594 @default.
• W3145745909 hasConcept C526805850 @default.
• W3145745909 hasConcept C55493867 @default.
• W3145745909 hasConcept C60644358 @default.
• W3145745909 hasConcept C71924100 @default.
• W3145745909 hasConcept C86803240 @default.
• W3145745909 hasConcept C96232424 @default.
• W3145745909 hasConcept C98274493 @default.
• W3145745909 hasConceptScore W3145745909C104317684 @default.
• W3145745909 hasConceptScore W3145745909C121608353 @default.
• W3145745909 hasConceptScore W3145745909C126322002 @default.
• W3145745909 hasConceptScore W3145745909C127561419 @default.
• W3145745909 hasConceptScore W3145745909C142724271 @default.

• next