Matches in SemOpenAlex for { <https://semopenalex.org/work/W3145874310> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W3145874310 abstract "Background: In patients with severe head injury, endotracheal suctioning (ES) is a potentially unsafe procedure, because it can increase intracranial pressure (ICP) and decrease cerebral perfusion pressure (CPP). Lidocaine has been shown to directly blunt ICP rises before ES, although it is not known whether the efficacy of lidocaine given endotracheally is comparable with that intravenously. The purpose of this study was evaluated the effects of ES on ICP with or without the use of lidocaine given endotracheally or intravenously in head trauma. Methods: Twenty patients admitted to the intensive care unit having traumatic brain injury with Glasgow Coma Scale ≤ 8 were evaluated. Patients were randomly given 1.5 mg/kg of 2% lidocaine intravenously (Group 1), 1 mg/kg of 2% lidocaine endotracheally (Group 2) or did not receive lidocaine (Group 3) prior to ES. The ICP, mean arterial pressure, heart rate and CPP were monitored continuously and were recorded prior and immediately after ES. Results: There was no significant increase in ICP after ES in group 1 (P = 0.56) and group 2 (P = 0.06) patients. However, the ICP increased after ES in group 3 patients (P = 0.0002). Conclusions: Our findings suggest that the administration of lidocaine endotracheally or intravenously before ES effectively prevents the ICP increase and CPP reduction in severe head trauma. Aiming for patient safety we propose the use of endotracheal lidocaine because intravenous drugs have a heightened risk of causing significant patient harm when used in error and preventable adverse drug events, are a prominent quality and cost issue in healthcare. J Neurol Res. 2013;3(2):51-55 doi: https://doi.org/10.4021/jnr201w" @default.
- W3145874310 created "2021-04-13" @default.
- W3145874310 creator A5015911349 @default.
- W3145874310 date "2013-01-01" @default.
- W3145874310 modified "2023-10-02" @default.
- W3145874310 title "Which is Safer to Avoid an Increase in ICP After Endotracheal Suctioning in Severe Head Injury: Intravenous or Endotracheal Lidocaine?" @default.
- W3145874310 doi "https://doi.org/10.4021/jnr201w" @default.
- W3145874310 hasPublicationYear "2013" @default.
- W3145874310 type Work @default.
- W3145874310 sameAs 3145874310 @default.
- W3145874310 citedByCount "0" @default.
- W3145874310 crossrefType "journal-article" @default.
- W3145874310 hasAuthorship W3145874310A5015911349 @default.
- W3145874310 hasBestOaLocation W31458743101 @default.
- W3145874310 hasConcept C141071460 @default.
- W3145874310 hasConcept C154281038 @default.
- W3145874310 hasConcept C157767197 @default.
- W3145874310 hasConcept C17624336 @default.
- W3145874310 hasConcept C2777975874 @default.
- W3145874310 hasConcept C2778716859 @default.
- W3145874310 hasConcept C2780149897 @default.
- W3145874310 hasConcept C2780954326 @default.
- W3145874310 hasConcept C3019038464 @default.
- W3145874310 hasConcept C42219234 @default.
- W3145874310 hasConcept C71924100 @default.
- W3145874310 hasConceptScore W3145874310C141071460 @default.
- W3145874310 hasConceptScore W3145874310C154281038 @default.
- W3145874310 hasConceptScore W3145874310C157767197 @default.
- W3145874310 hasConceptScore W3145874310C17624336 @default.
- W3145874310 hasConceptScore W3145874310C2777975874 @default.
- W3145874310 hasConceptScore W3145874310C2778716859 @default.
- W3145874310 hasConceptScore W3145874310C2780149897 @default.
- W3145874310 hasConceptScore W3145874310C2780954326 @default.
- W3145874310 hasConceptScore W3145874310C3019038464 @default.
- W3145874310 hasConceptScore W3145874310C42219234 @default.
- W3145874310 hasConceptScore W3145874310C71924100 @default.
- W3145874310 hasLocation W31458743101 @default.
- W3145874310 hasOpenAccess W3145874310 @default.
- W3145874310 hasPrimaryLocation W31458743101 @default.
- W3145874310 hasRelatedWork W1969233462 @default.
- W3145874310 hasRelatedWork W2021737563 @default.
- W3145874310 hasRelatedWork W2040495258 @default.
- W3145874310 hasRelatedWork W2041514478 @default.
- W3145874310 hasRelatedWork W2059495212 @default.
- W3145874310 hasRelatedWork W2106455466 @default.
- W3145874310 hasRelatedWork W2160183581 @default.
- W3145874310 hasRelatedWork W2356610018 @default.
- W3145874310 hasRelatedWork W2901862417 @default.
- W3145874310 hasRelatedWork W3145874310 @default.
- W3145874310 isParatext "false" @default.
- W3145874310 isRetracted "false" @default.
- W3145874310 magId "3145874310" @default.
- W3145874310 workType "article" @default.