FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146022570> ?p ?o ?g. }

• W3146022570 abstract "Acute myeloid leukemia (AML) is a heterogeneous group of disorders with distinct characteristics and prognoses. Although cytogenetic changes and gene mutations are associated with AML prognosis, there is a need to identify further factors. CD56 is considered a prognostic factor for AML, which is abnormally expressed in leukemia cells. However, a clear consensus for this surface molecule is lacking, which has prompted us to investigate its prognostic significance. Bone marrow samples of de novo non-M3 AML were collected to detect CD56 expression using multiparameter flow cytometry (FCM). As a result, the CD56 expression in de novo non-M3 AML was found to be significantly higher than that in acute lymphoma leukemia (ALL, <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>P</mi> <mo>=</mo> <mn>0.017</mn> </math> ) and healthy controls ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>P</mi> <mo>=</mo> <mn>0.02</mn> </math> ). The X-Tile program produced a CD56 cutoff point at a relative expression level of 24.62%. Based on this cutoff point, high CD56 expression was observed in 29.21% of de novo non-M3 AML patients. CD56-high patients had a poor overall survival (OS, <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>P</mi> <mo>=</mo> <mn>0.015</mn> </math> ) compared to CD56-low patients. Bone marrow transplantation (BMT) improved OS ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mi>P</mi> <mo>=</mo> <mn>0.004</mn> </math> ), but a poor genetic risk was associated with an inferior OS ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mi>P</mi> <mo>=</mo> <mn>0.002</mn> </math> ). Compared with CD56-low patients, CD56-high patients had lower peripheral blood platelet (PLT) counts ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M6> <mi>P</mi> <mo>=</mo> <mn>0.010</mn> </math> ). Our research confirmed that high CD56 expression is associated with adverse clinical outcomes in de novo non-M3 AML patients, indicating that CD56 could be used as a prognostic marker for a more precise stratification of de novo non-M3 AML patients." @default.
• W3146022570 created "2021-04-13" @default.
• W3146022570 creator A5004707897 @default.
• W3146022570 creator A5005876602 @default.
• W3146022570 creator A5010540700 @default.
• W3146022570 creator A5012990898 @default.
• W3146022570 creator A5013087597 @default.
• W3146022570 creator A5019858879 @default.
• W3146022570 creator A5021125002 @default.
• W3146022570 creator A5032068710 @default.
• W3146022570 creator A5033720006 @default.
• W3146022570 creator A5045928785 @default.
• W3146022570 creator A5051477761 @default.
• W3146022570 creator A5055162501 @default.
• W3146022570 creator A5056078581 @default.
• W3146022570 creator A5060775764 @default.
• W3146022570 creator A5068450687 @default.
• W3146022570 creator A5077606926 @default.
• W3146022570 creator A5081855118 @default.
• W3146022570 creator A5086183173 @default.
• W3146022570 date "2021-04-08" @default.
• W3146022570 modified "2023-10-17" @default.
• W3146022570 title "Prognostic Significance of CD56 Antigen Expression in Patients with De Novo Non-M3 Acute Myeloid Leukemia" @default.
• W3146022570 cites W1976187277 @default.
• W3146022570 cites W2047008143 @default.
• W3146022570 cites W2062483137 @default.
• W3146022570 cites W2091075427 @default.
• W3146022570 cites W2111121001 @default.
• W3146022570 cites W2126302967 @default.
• W3146022570 cites W2133650808 @default.
• W3146022570 cites W2159507916 @default.
• W3146022570 cites W2292587137 @default.
• W3146022570 cites W2336690489 @default.
• W3146022570 cites W2338603660 @default.
• W3146022570 cites W2339658711 @default.
• W3146022570 cites W2470876555 @default.
• W3146022570 cites W2502512310 @default.
• W3146022570 cites W2519214558 @default.
• W3146022570 cites W2559537906 @default.
• W3146022570 cites W2582199324 @default.
• W3146022570 cites W2725930552 @default.
• W3146022570 cites W2738658820 @default.
• W3146022570 cites W2750812653 @default.
• W3146022570 cites W2754994183 @default.
• W3146022570 cites W2767772633 @default.
• W3146022570 cites W2769280723 @default.
• W3146022570 cites W2774586064 @default.
• W3146022570 cites W2783051269 @default.
• W3146022570 cites W2784085212 @default.
• W3146022570 cites W2792481575 @default.
• W3146022570 cites W2792645441 @default.
• W3146022570 cites W2794559669 @default.
• W3146022570 cites W2883232437 @default.
• W3146022570 cites W2887033855 @default.
• W3146022570 cites W2890635518 @default.
• W3146022570 cites W2918095490 @default.
• W3146022570 cites W2919559570 @default.
• W3146022570 cites W2923510542 @default.
• W3146022570 cites W2958488683 @default.
• W3146022570 cites W2961912877 @default.
• W3146022570 cites W2969571340 @default.
• W3146022570 cites W3174285238 @default.
• W3146022570 cites W2064733829 @default.
• W3146022570 doi "https://doi.org/10.1155/2021/1929357" @default.
• W3146022570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8049794" @default.
• W3146022570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33928145" @default.
• W3146022570 hasPublicationYear "2021" @default.
• W3146022570 type Work @default.
• W3146022570 sameAs 3146022570 @default.
• W3146022570 citedByCount "3" @default.
• W3146022570 countsByYear W31460225702021 @default.
• W3146022570 countsByYear W31460225702022 @default.
• W3146022570 countsByYear W31460225702023 @default.
• W3146022570 crossrefType "journal-article" @default.
• W3146022570 hasAuthorship W3146022570A5004707897 @default.
• W3146022570 hasAuthorship W3146022570A5005876602 @default.
• W3146022570 hasAuthorship W3146022570A5010540700 @default.
• W3146022570 hasAuthorship W3146022570A5012990898 @default.
• W3146022570 hasAuthorship W3146022570A5013087597 @default.
• W3146022570 hasAuthorship W3146022570A5019858879 @default.
• W3146022570 hasAuthorship W3146022570A5021125002 @default.
• W3146022570 hasAuthorship W3146022570A5032068710 @default.
• W3146022570 hasAuthorship W3146022570A5033720006 @default.
• W3146022570 hasAuthorship W3146022570A5045928785 @default.
• W3146022570 hasAuthorship W3146022570A5051477761 @default.
• W3146022570 hasAuthorship W3146022570A5055162501 @default.
• W3146022570 hasAuthorship W3146022570A5056078581 @default.
• W3146022570 hasAuthorship W3146022570A5060775764 @default.
• W3146022570 hasAuthorship W3146022570A5068450687 @default.
• W3146022570 hasAuthorship W3146022570A5077606926 @default.
• W3146022570 hasAuthorship W3146022570A5081855118 @default.
• W3146022570 hasAuthorship W3146022570A5086183173 @default.
• W3146022570 hasBestOaLocation W31460225701 @default.
• W3146022570 hasConcept C126322002 @default.
• W3146022570 hasConcept C143998085 @default.
• W3146022570 hasConcept C203014093 @default.
• W3146022570 hasConcept C2778461978 @default.
• W3146022570 hasConcept C2778729363 @default.
• W3146022570 hasConcept C2779282312 @default.
• W3146022570 hasConcept C2780007613 @default.

• next