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- W3146025658 abstract "Objective To explore whether exercise training can ameliorate estrogen deficiency-induced depression-like behavior and its mechanisms,so as to provide evidence for treating menopausal depression with exercise.Methods A total of 60 female adult C57 BL /6J mice were randomly assigned to Sham-sedentary(Sham),Sham-exercise(Sham + Ex),Ovx-sedentary(Ovx) and Ovxexercise(Ovx + Ex) groups.Sham operation or bilateral Ovx was performed.After recovery for 1 week,Sham + Ex and Ovx + Ex mice were adapted to the treadmill for 5 weeks.We use sucrose consumption test,open field test and tail suspension test to inspect the mice of behavior change; then the mice were decapitated,and the serum and hippocampus samples were collected.5-hydroxytryptamine(5-HT),indoleamine 2,3-dioxygenase(IDO) and inflammatory cytokine in the hippocampus were determined using a commercial ELISA kit.Results Compared with Sham mice,Ovx mice developed depression-like behaviors,including loss of interests,decreased exploratory behavior and increased behavioral despair,and exercise training could ameliorate these depression-like behaviors.Compared with the Sham group,Ovx group had significantly decreased hippocampal 5-HT level(P 0.01) and significantly increased IDO level(P 0.05) in the hippocampus,which were reversed by exercise training.The hippocampal levels of proinflammatory cytokines,IL-1β(P 0.05),IL-6(P 0.01) and IFN-γ(P 0.01) in Ovx group were significantly increased compared to Sham mice,while the anti-inflammatory cytokines,IL-4(P 0.01) and IL-10(P 0.05),were significantly decreased in Ovx mice; exercise training could also reverse the alterations of IL-1β,IFN-γ and IL-4 levels in Ovx mice.Conclusion Exercise training can ameliorate estrogen deficiency-induced depression-like behaviors,which may be through improving inflammation in the hippocampus." @default.
- W3146025658 created "2021-04-13" @default.
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- W3146025658 date "2015-01-01" @default.
- W3146025658 modified "2023-09-24" @default.
- W3146025658 title "Effect of exercise on estrogen deficiency-induced depression-like behavior and its inflammatory mechanisms" @default.
- W3146025658 hasPublicationYear "2015" @default.
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