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• W3146025874 abstract "Peroxisome proliferator activated receptor gamma coactivator 1a (PGC-1a) induced by hypoxia reg- ulates mitochondrial biogenesis and oxidative stress. However, the potential role of PGC-1a in hypoxia-pro- moted proliferation of pulmonary arterial vascular smooth muscle cells (PASMCs) is completely unknown. In this study, we found that hypoxia significantly induced the expression of PGC-1a in cultured PASMCs and activated mitochondrial biogenesis through upregulation of nuclear respiratory factor-1 and mitochondria transcription factor A in a time-dependent manner. Knockdown of PGC-1a by siRNA abrogated hypoxia-induced PASMCs proliferation via the downregulation of PCNA, cyclinA, and cyclinE. Furthermore, we observed that PI3K/Akt signaling path- way was involved in hypoxia induced PGC-1a expression and PASMCs proliferation. Taken together, these datas reveal PGC-1a as the key regulator to mediate mitochon- drial biogenesis and the proliferation of PASMCs at an early stage of hypoxic exposure. This process might bring to light a potential adaptive mechanism for PASMCs to minimize hypoxic damage and our novel findings provide new insight into the development of hypoxic pulmonary hypertension." @default.
• W3146025874 created "2021-04-13" @default.
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• W3146025874 date "2012-01-01" @default.
• W3146025874 modified "2023-09-27" @default.
• W3146025874 title "The key role of PGC-1a in mitochondrial biogenesis and the proliferation of pulmonary artery vascular smooth muscle cells at an early stage of hypoxic exposure" @default.
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• W3146025874 hasPublicationYear "2012" @default.
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