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• W3146028851 abstract "-induced 肝纤维变性上的 PNS 的效果与组织化学、生物化学的分析被学习。转变生长因素(TGF )-1, 光滑的肌肉肌动朊(-SMA), 和骨胶原我 mRNA 表示被反向的 transcriptase 聚合酶链反应(RT-PCR ) 决定。同时，蛋白质表达式-SMA,铺平骨胶原我， phosphorylation-Janus 激活 kinase 信号变换器( p-Jak2 )/ Jak2 ，并且抄写( p-Stat )的phosphorylation使活跃之物 3 / Stat3 被 immunohistochemistry 决定，/或 immunoblotting.ResultsPNS 处理显著地改进了由减少的浆液显示了丙氨酸 aminotransferase 和 aspartate aminotransferase 的酶的活动的老鼠的肝函数。组织病理学说的结果显示 PNS 减轻了肝损坏并且减少了含纤维的 septa 的形成。而且， PNS 显著地减少了肝 hydroxyproline 和我，-SMA, TGF-1 ， p-Jak2 / Jak2 ，和在老鼠肝纤维变性的 p-Stat3 / Stat3 建模的骨胶原和 HSCs.ConclusionPNS 罐头的显著地稀释的表情由表明 transduction 的 modulating Jak2/Stat3 减轻肝纤维变性小径，它可以是它的机制之一压制肝的纤维变性。" @default.
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• W3146028851 date "2016-01-01" @default.
• W3146028851 modified "2023-10-08" @default.
• W3146028851 title "Panax notoginseng saponins ameliorates experimental hepatic fibrosis and hepatic stellate cell proliferation by inhibiting the Jak2/Stat3 pathways" @default.
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