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- W3146031021 abstract "Objective To screen the target genes regulated by the transcriptional repressor Syk (L) so as to explore the mechanism of Syk(L) in suppressing breast cancer.Methods Adeno-XTM expression system from Clontech Company was used to construct the adenovirus-Syk.Syk negative breast cancer cells of the line MB231 were cultured and infected with adeno-Syk(L),adeno-Syk(S),and the control adeno-Lac Z respectively,cDNA microarray was used to screen the genes regulated by Syk (L) and Syk (S).Northern blotting was used to examine the cDNA microarray results.Results The transcriptional repressor Syk (L) was able to down-regulate the expression of the oncogenes ID1,cyclin D1,Fra1,and B-myb in the breast cancer cells.Northern blotting confirmed this regulation.Conclusion Syk (L) suppresses the progression of breast cancer by down regulating the expression of the oncogenes ID1,cyclin D1,Fra1,and B-myb." @default.
- W3146031021 created "2021-04-13" @default.
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- W3146031021 date "2007-01-01" @default.
- W3146031021 modified "2023-09-24" @default.
- W3146031021 title "Spleen tyrosine kinase(L)suppresses breast cancer development by downregulating the expression of cyclin D1,ID1,B-myb and Fra1" @default.
- W3146031021 hasPublicationYear "2007" @default.
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