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• W3146032012 abstract "After passage through biological barriers, nanomaterials inevitably end up in contact with the vascular endothelium and can induce cardiovascular damage. In this study the toxicity and sublethal effects of 6 types of nanoparticle, including 4 of industrial and biomedical importance, on human endothelial cells was investigated using different in vitro assays. The results show that all the particles investigated induce some level of damage to the cells and that silver particles were most toxic, followed by titanium dioxide. Furthermore endothelial cells were shown to be more susceptible when exposed to silver nanoparticles under flow conditions in a bioreactor. The study underlines that although simple in vitro tests are useful to screen compounds and to identify the type of effect induced on cells, they may not be sufficient to define safe exposure limits. Therefore, once initial toxicity screening has been conducted on nanomaterials, it is necessary to develop more physiologically relevant in vitro models to better understand how nanomaterials can impact on human health." @default.
• W3146032012 created "2021-04-13" @default.
• W3146032012 creator A5003774544 @default.
• W3146032012 creator A5065517445 @default.
• W3146032012 date "2014-01-01" @default.
• W3146032012 modified "2023-09-27" @default.
• W3146032012 title "In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response" @default.
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• W3146032012 hasPublicationYear "2014" @default.
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