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- W3146036372 abstract "We synthesized c(RGDyK)-coupled superparamagnetic iron oxide nanoparticles for spe- cific delivery of large amount of doxorubicin to avb3 integrin rich tumor cells (RDSP) by using a novel triplex hands coupling reagent tris-succinimidyl ami- notriacetate and evaluated their structure, drug release, target cell uptake, and cytotoxic effects. Besides the high-trapping efficient for magnetic targeting, RDSP also has integrin avb3 targeting property. Moreover, RDSP shows a high-drug load ratio and can carry a large amount of doxorubicin to the target tumor cells. Compare with those of doxorubicin coupled DSP without peptide c(RGDyK) modification, RDSP shows an increase uptake by target tumor cells and stronger tumor cell cytotoxicity. This investigate provides an idiographic way for targeted delivery therapeutic agents to tumors with high efficiency and low-carrier toxicity." @default.
- W3146036372 created "2021-04-13" @default.
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- W3146036372 date "2013-01-01" @default.
- W3146036372 modified "2023-09-27" @default.
- W3146036372 title "Synthesis and evaluation of c(RGDyK)-coupled superparamagnetic iron oxide nanoparticles for specific delivery of large amount of doxorubicin to tumor cell" @default.
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