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- W3146038673 abstract "Objective To study the effect of chronic arsenic poisoning on the renal proximal convoluted tubules epithelial cell apoptosis in rats.Methods Thirty healthy clean grade SD rats were randomly divided into three groups,the high dose arsenic exposure group(10.0 mg/kg),the low dose arsenic exposure group(0.4 mg/kg),and the control group.The rats were treated with the arsenic through drinking water,for 6 consecutive months.In the end of experiment,the kidneys were collected for the proximal convoluted tubules epithelial apoptosis examination by TUNEL.Results The renal proximal convoluted tubules epithelial cells of rats with arsenism appeared vacuolar degeneration.The brush border of lumen surface reduced and fell off,more deciduous and perishing cells could be seen.The nuclei became pyknotic and hyperchromatic.The chromatins were condensed to gather in karyotheca.Compared with the control group,in the high and low doses arsenic exposure groups,higher account was presented in the renal proximal convoluted tubules epithelial apoptosis cells,and the gray values were lower(P0.05).With the increase of arsenic exposure doses,the amounts of apoptosis cells appeared an increasing trend,the gray values appeared decreasing trend.Conclusion Arsenism can lead to the renal proximal convoluted tubules epithelial cell apoptosis,with dose-dependent manner." @default.
- W3146038673 created "2021-04-13" @default.
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- W3146038673 date "2010-01-01" @default.
- W3146038673 modified "2023-09-24" @default.
- W3146038673 title "Renal Proximal Convoluted Tubules Epithelial Cell Apoptosis in Rats with Arsenism" @default.
- W3146038673 hasPublicationYear "2010" @default.
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