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- W3146040256 abstract "Objective To investigate the regulation of Bifidobacterium bifidum surface molecules whole peptidoglycan (WPG), lipoteichoic acid (LTA) on apoptosis of murine thymocytes induced by LPS in vivo. Methods Apoptosis of murine thymocytes in the cortex in vivo was analysed with methods of DNA gel electrophoresis and terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL). Results in vivo, the induction of apoptosis in murine thymocytes by LPS was significantly inhibited by WPG and LTA. in vitro, LPS induced significantly more TNF α and NO which released from murine macrophages than all of the tested surface molecules did. When WPG and LTA were combined with LPS respectively in stimulating murine macrophages, TNF α and NO release significantly decreased compared with that induced by LPS alone. SMT, a selective inhibitor of inducible nitric oxide synthase, not only decreased NO activity in murine macrophages induced by LPS in vitro, but also inhibited apoptosis of murine thymocytes induced by LPS in vivo. Conclusion The results suggest that WPG and LTA reduce LPS stimulated TNF α and NO release, then down regulate apoptosis of murine thymocytes induced by LPS in vivo." @default.
- W3146040256 created "2021-04-13" @default.
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- W3146040256 date "1999-01-01" @default.
- W3146040256 modified "2023-09-23" @default.
- W3146040256 title "Regulation of Bifidobacterium bifidum surface molecules on apoptosis of murine thymocytes induced by LPS in vivo" @default.
- W3146040256 hasPublicationYear "1999" @default.
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