FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146040617> ?p ?o ?g. }

• W3146040617 endingPage "10" @default.
• W3146040617 startingPage "5" @default.
• W3146040617 abstract "通过观察Endostar联合放疗对肺腺癌A549细胞增值及TGF-β1、HIF-1α表达的影响，初步探讨重组血管内皮抑素的放疗增敏机制。方法：将培养至对数生长期的A549细胞分为对照组、单纯放疗组、恩度组、联合组，检测各组A549细胞增殖率及TGF-β1、HIF-1α蛋白和mRNA表达情况。结果：1) 除对照组外，各组细胞的增殖随时间的改变都受到不同程度的抑制，以联合组最为明显，差异具有统计学意义(p ；2) 处理后各组A549细胞TGF-β1、HIF-1α的分泌下降，24 h以放疗组及联合组TGF-β1、HIF-1α表达量明显下降 (p ；3) PCR扩增后，各处理组 TGF-β1、HIF-1α mRNA的表达随着时间变化均表现出下降趋势，联合组在24 h差异有显著统计学意义(p 。结论：恩度联合放疗可显著抑制肺腺癌A549细胞增殖及TGF-β1、HIF-1α的表达，恩度可能通过下调TGF-β1、HIF-1α的表达进而发挥放疗增敏作用。To observe the effect of Endostar combined with Radiotherapy on the expression of Transforming Growth Factor-beta 1 (TGF-β1) and Hypoxia-induced factor-1 (HIF-1α) in lung adenocarcinoma A549 cells and to discuss the possible mechanisms. Methods: To culture the A549 cell, when the cells achieve Logarithmic phase and there are four groups: Control group; Endostar group; Radiotherapy group; Endostar in combination with Radiotherapy. Cell proliferate rate was measured by CCK8, and the expression level of TGF-beta 1 and HIF-1α protein and mRNA of A549 cells in each group were examined by ELISA and PCR. Result: 1) Besides control group, the proliferation of tumor cells in each group are subject to different degree of inhibition. Compared with control and Endostar groups, there is a significant difference of proliferate inhibition in Endostar combined with Radiotherapy group (p β1 and HIF-1 of A549 cells in each group appears to be declining differently. The Radiotherapy group and combined group have a significant difference in cell proliferation at 24 hours, compared to control group (p β1 and HIF-1α mRNA over time (0 - 24 hours) compared with the control group, all treatment groups showed a decreasing trend. After 24 hours of treatment, Compared with control group and Endostar group, the difference in the combined group was statistically sig- nificant (p Conclusion: Endostar combined with Radiotherapy could significantly enhance the inhibition of proliferate of cells and expressions of TGF-β1 and HIF-1α in tumor cells. Thus enhance the inhibition of tumor angio- genesis and metastatic." @default.
• W3146040617 created "2021-04-13" @default.
• W3146040617 creator A5086744109 @default.
• W3146040617 date "2012-01-01" @default.
• W3146040617 modified "2023-09-26" @default.
• W3146040617 title "Effect of Recombinant Endostatin in Combination with Radiotherapy on the Expression of TGF-β1 and HIF-1α in Lung Adenocarcinoma Cell A549" @default.
• W3146040617 cites W1963767618 @default.
• W3146040617 cites W1992662084 @default.
• W3146040617 cites W1995273540 @default.
• W3146040617 cites W2012998775 @default.
• W3146040617 cites W2047052596 @default.
• W3146040617 cites W2075780259 @default.
• W3146040617 cites W2078559905 @default.
• W3146040617 cites W2091068407 @default.
• W3146040617 cites W2092056907 @default.
• W3146040617 cites W2101503902 @default.
• W3146040617 doi "https://doi.org/10.12677/acrpo.2012.12002" @default.
• W3146040617 hasPublicationYear "2012" @default.
• W3146040617 type Work @default.
• W3146040617 sameAs 3146040617 @default.
• W3146040617 citedByCount "1" @default.
• W3146040617 countsByYear W31460406172016 @default.
• W3146040617 crossrefType "journal-article" @default.
• W3146040617 hasAuthorship W3146040617A5086744109 @default.
• W3146040617 hasBestOaLocation W31460406171 @default.
• W3146040617 hasConcept C104317684 @default.
• W3146040617 hasConcept C118131993 @default.
• W3146040617 hasConcept C121608353 @default.
• W3146040617 hasConcept C126322002 @default.
• W3146040617 hasConcept C143998085 @default.
• W3146040617 hasConcept C185592680 @default.
• W3146040617 hasConcept C2777714996 @default.
• W3146040617 hasConcept C2781182431 @default.
• W3146040617 hasConcept C40767141 @default.
• W3146040617 hasConcept C502942594 @default.
• W3146040617 hasConcept C55493867 @default.
• W3146040617 hasConcept C71924100 @default.
• W3146040617 hasConcept C81729549 @default.
• W3146040617 hasConceptScore W3146040617C104317684 @default.
• W3146040617 hasConceptScore W3146040617C118131993 @default.
• W3146040617 hasConceptScore W3146040617C121608353 @default.
• W3146040617 hasConceptScore W3146040617C126322002 @default.
• W3146040617 hasConceptScore W3146040617C143998085 @default.
• W3146040617 hasConceptScore W3146040617C185592680 @default.
• W3146040617 hasConceptScore W3146040617C2777714996 @default.
• W3146040617 hasConceptScore W3146040617C2781182431 @default.
• W3146040617 hasConceptScore W3146040617C40767141 @default.
• W3146040617 hasConceptScore W3146040617C502942594 @default.
• W3146040617 hasConceptScore W3146040617C55493867 @default.
• W3146040617 hasConceptScore W3146040617C71924100 @default.
• W3146040617 hasConceptScore W3146040617C81729549 @default.
• W3146040617 hasIssue "02" @default.
• W3146040617 hasLocation W31460406171 @default.
• W3146040617 hasOpenAccess W3146040617 @default.
• W3146040617 hasPrimaryLocation W31460406171 @default.
• W3146040617 hasRelatedWork W1985538428 @default.
• W3146040617 hasRelatedWork W2023809974 @default.
• W3146040617 hasRelatedWork W2081501617 @default.
• W3146040617 hasRelatedWork W2110146698 @default.
• W3146040617 hasRelatedWork W2357839168 @default.
• W3146040617 hasRelatedWork W2406858132 @default.
• W3146040617 hasRelatedWork W2765305098 @default.
• W3146040617 hasRelatedWork W3201366095 @default.
• W3146040617 hasRelatedWork W4220903368 @default.
• W3146040617 hasRelatedWork W2140890293 @default.
• W3146040617 hasVolume "01" @default.
• W3146040617 isParatext "false" @default.
• W3146040617 isRetracted "false" @default.
• W3146040617 magId "3146040617" @default.
• W3146040617 workType "article" @default.