Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146043198> ?p ?o ?g. }
- W3146043198 abstract "Inflammatory Bowel Disease is a complex, non-Mendelian auto-inflammatory/auto-immune disorder with increasing incidence worldwide. The pathogenesis of this disease remains elusive; however, the current theory postulates that the inflammation of the bowel is caused by an aberrant immune response to commensal gut bacterial. It is believed that this abnormal response occurs in a genetically susceptible host after exposure to environmental triggers. Research has still yet to prove a universal trigger for all cases of IBD Currently the genotype-phenotype data is too limited to provide any kind of substantial diagnostic genetic test and relative risk data provides as 1 in 10-20 risk for first-degree family members. Roughly 20-25% of disease heritability is explained and researchers believe an additional portion of the “missing heritability” may be found in either risk alleles with small effect sizes or the non-coding regions of the genome affecting gene expression through gene-to-gene interactions. Studies have shown patients are open and receptive to genetic counseling services; however, today’s data provides counselors with little useful information but does not rule out the need for genetic counseling services. In the future a panel of many small effect genes may help to elucidate those at the greatest risk for disease. A COMPREHENSIVE EXAMINATION OF INFLAMMATORY BOWEL DISEASE FOR GENETIC COUNSELORS Kathryn Menne Rice, M.S. University of Pittsburgh, 2014" @default.
- W3146043198 created "2021-04-13" @default.
- W3146043198 creator A5016832149 @default.
- W3146043198 creator A5061311983 @default.
- W3146043198 date "2014-01-01" @default.
- W3146043198 modified "2023-09-23" @default.
- W3146043198 title "A COMPREHENSIVE EXAMINATION OF INFLAMMATORY BOWEL DISEASE FOR GENETIC COUNSELORS by" @default.
- W3146043198 cites W128994328 @default.
- W3146043198 cites W1534517380 @default.
- W3146043198 cites W1599664643 @default.
- W3146043198 cites W1607497471 @default.
- W3146043198 cites W1794635866 @default.
- W3146043198 cites W1969401189 @default.
- W3146043198 cites W1969510944 @default.
- W3146043198 cites W1974503802 @default.
- W3146043198 cites W1976285273 @default.
- W3146043198 cites W1980991473 @default.
- W3146043198 cites W1983251816 @default.
- W3146043198 cites W1983600826 @default.
- W3146043198 cites W1985513953 @default.
- W3146043198 cites W1986079650 @default.
- W3146043198 cites W1986146810 @default.
- W3146043198 cites W1986376353 @default.
- W3146043198 cites W1991704577 @default.
- W3146043198 cites W1997319837 @default.
- W3146043198 cites W2001828968 @default.
- W3146043198 cites W2013873874 @default.
- W3146043198 cites W2015872230 @default.
- W3146043198 cites W2025988193 @default.
- W3146043198 cites W2032537180 @default.
- W3146043198 cites W2033082339 @default.
- W3146043198 cites W2033206630 @default.
- W3146043198 cites W2033275384 @default.
- W3146043198 cites W2037573239 @default.
- W3146043198 cites W2046888587 @default.
- W3146043198 cites W2047208232 @default.
- W3146043198 cites W2047338785 @default.
- W3146043198 cites W2047852273 @default.
- W3146043198 cites W2054182776 @default.
- W3146043198 cites W2056374414 @default.
- W3146043198 cites W2057447694 @default.
- W3146043198 cites W2061585193 @default.
- W3146043198 cites W2068661507 @default.
- W3146043198 cites W2074003071 @default.
- W3146043198 cites W2074558856 @default.
- W3146043198 cites W2074699954 @default.
- W3146043198 cites W2078621117 @default.
- W3146043198 cites W2089511883 @default.
- W3146043198 cites W2094464340 @default.
- W3146043198 cites W2099855942 @default.
- W3146043198 cites W2099931884 @default.
- W3146043198 cites W2101742301 @default.
- W3146043198 cites W2105058392 @default.
- W3146043198 cites W2105952194 @default.
- W3146043198 cites W2107279356 @default.
- W3146043198 cites W2111270515 @default.
- W3146043198 cites W2122242614 @default.
- W3146043198 cites W2127242372 @default.
- W3146043198 cites W2128759554 @default.
- W3146043198 cites W2143625465 @default.
- W3146043198 cites W2148293739 @default.
- W3146043198 cites W2152751713 @default.
- W3146043198 cites W2153266003 @default.
- W3146043198 cites W2153915282 @default.
- W3146043198 cites W2158507534 @default.
- W3146043198 cites W2161374773 @default.
- W3146043198 cites W2166021109 @default.
- W3146043198 cites W2167149704 @default.
- W3146043198 cites W2169102457 @default.
- W3146043198 cites W2169567789 @default.
- W3146043198 cites W2337711722 @default.
- W3146043198 cites W237723998 @default.
- W3146043198 cites W3029052526 @default.
- W3146043198 cites W2065591755 @default.
- W3146043198 cites W3148951363 @default.
- W3146043198 hasPublicationYear "2014" @default.
- W3146043198 type Work @default.
- W3146043198 sameAs 3146043198 @default.
- W3146043198 citedByCount "0" @default.
- W3146043198 crossrefType "journal-article" @default.
- W3146043198 hasAuthorship W3146043198A5016832149 @default.
- W3146043198 hasAuthorship W3146043198A5061311983 @default.
- W3146043198 hasConcept C104317684 @default.
- W3146043198 hasConcept C135763542 @default.
- W3146043198 hasConcept C142724271 @default.
- W3146043198 hasConcept C144621757 @default.
- W3146043198 hasConcept C153209595 @default.
- W3146043198 hasConcept C161890455 @default.
- W3146043198 hasConcept C175783326 @default.
- W3146043198 hasConcept C180754005 @default.
- W3146043198 hasConcept C203014093 @default.
- W3146043198 hasConcept C2778260677 @default.
- W3146043198 hasConcept C2779134260 @default.
- W3146043198 hasConcept C2780673598 @default.
- W3146043198 hasConcept C54355233 @default.
- W3146043198 hasConcept C60644358 @default.
- W3146043198 hasConcept C71924100 @default.
- W3146043198 hasConcept C86803240 @default.
- W3146043198 hasConceptScore W3146043198C104317684 @default.
- W3146043198 hasConceptScore W3146043198C135763542 @default.