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- W3146044298 abstract "Objectives To investigate the effects of cadmium exposure on insulin expression in rats.Methods Eighteen adult SD rats were administered cadmium subcutaneously(0.5,1.0,and 2.0 mg/kg·bw).The effects on endocrine of pancreas were assessed.The levels of cadmium and zinc in pancreas,blood and urine glucose,serum insulin and urine NAG(N-acyetyl-β-glucosaminidase)were determined.The gene expressions of metallothionein(MT)and insulin were also measured,and the oral glucose tolerance tests(OGTT)were carried out.Results The contents of cadmium in pancreas in cadmium-treated rats were higher than that in the control group,which was associated with slight increase of zinc in pancreas.Cadmium-exposed rats(1.0 and 2.0 mg/kg·bw)demonstrated a marked glucose intolerance.But the levels of serum insulin did not change significantly after cadmium administration,and the UNAG had no change in Cd-treated group.The gene expression of insulin decreased in 1.0 and 2.0 mg/kg·bw cadmium-exposed groups,compared with the control group.The expression of MT-I was higher in the groups exposed to 1.0 and 2.0 mg/kg·bw cadmium while the expression of MT-II was higher in the group exposed to 2.0 mg/kg·bw cadmium.Conclusions Cadmium may be accumulated in the pancreas,resulting in the change of the expression of insulin,MT-I and MT-II genes.Cadmium can influence the biosynthesis of insulin,but does not induce the release of insulin.The dysfunction of pancreas occurs earlier than that of kidney after administration of cadmium." @default.
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- W3146044298 date "2007-01-01" @default.
- W3146044298 modified "2023-09-26" @default.
- W3146044298 title "Insulin Expression in Rats Exposed to Cadmium" @default.
- W3146044298 hasPublicationYear "2007" @default.
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