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• W3146045363 abstract "Data on the association between -1607 1G ( 2G polymorphism in the promoter region of matrix metalloproteinase-1 (MMP1) and nasopharyngeal carci- noma (NPC) are conflicting. The aim of this study was to confirm whether this polymorphism was a causative factor of NPC. We searched PubMed, Embase, and China National Knowledge Infrastructure (CNKI) for studies on the present topic. A total of four publications (1,044 NPC patients and 1,284 healthy control subjects) were included and meta-analysis was performed to assess the association between -1607 1G ( 2G polymorphism and NPC risk. Odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated for 1G1G versus 2G2G, 1G1G ? 1G2G versus 2G2G, 1G1G versus 1G2G ? 2G2G, 1G versus 2G, and 1G2G versus 2G2G contrast models. Meta-analysis results showed significantly reduced risk of NPC associated with the 1G1G versus 2G2G, 1G versus 2G and 1G2G versus 2G2G contrast models (OR = 0.61, 95 % CI 0.49-0.77; OR = 0.78, 95 % CI 0.65-0.92; OR = 0.86, 95 % CI 0.74-0.99, respectively). When we continued to perform subgroup analysis by ethnicity, the significant association persisted in Asian population and was most pronounced under the 1G2G versus 2G2G model (OR = 0.85, 95 % CI 0.73-0.99). These data suggested that MMP1 -1607 1G ( 2G polymorphism was associated with reduced risk of NPC, particularly in the population of Asian descent." @default.
• W3146045363 created "2021-04-13" @default.
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• W3146045363 date "2015-01-01" @default.
• W3146045363 modified "2023-09-27" @default.
• W3146045363 title "Matrix Metalloproteinase-1 (MMP1) Polymorphism is Associated with Lowered Risk of Nasopharyngeal Carcinoma in Asian Population" @default.
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