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- W3146045568 endingPage "101077" @default.
- W3146045568 startingPage "101077" @default.
- W3146045568 abstract "Abnormally alternative splicing events are common hallmark of diverse types of cancers. Splicing variants with aberrant functions play an important role in cancer development. Most importantly, a growing body of evidence has supported that alternative splicing might play a significant role in the therapeutic resistance of tumors. Targeted therapy and immunotherapy are the future directions of tumor therapy; however, the loss of antigen targets on the tumor cells surface and alterations in drug efficacy have resulted in the failure of targeted therapy and immunotherapy. Interestingly, abnormal alternative splicing, as a strategy to regulate gene expression, is reportedly involved in the reprogramming of cell signaling pathways and epitopes on the tumor cell surface by changing splicing patterns of genes, thus rendering tumors resisted to targeted therapy and immunotherapy. Accordingly, increased knowledge regarding abnormal alternative splicing in tumors may help predict therapeutic resistance during targeted therapy and immunotherapy and lead to novel therapeutic approaches in cancer. Herein, we provide a brief synopsis of abnormal alternative splicing events in cancer progression and therapeutic resistance." @default.
- W3146045568 created "2021-04-13" @default.
- W3146045568 creator A5035828773 @default.
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- W3146045568 creator A5065155864 @default.
- W3146045568 creator A5083172580 @default.
- W3146045568 creator A5083894361 @default.
- W3146045568 date "2021-06-01" @default.
- W3146045568 modified "2023-10-17" @default.
- W3146045568 title "Abnormal alternative splicing promotes tumor resistance in targeted therapy and immunotherapy" @default.
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- W3146045568 doi "https://doi.org/10.1016/j.tranon.2021.101077" @default.