Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146050608> ?p ?o ?g. }
- W3146050608 endingPage "129880" @default.
- W3146050608 startingPage "129880" @default.
- W3146050608 abstract "Abstract Nitric oxide (NO) is an epoch-making cellular signaling molecule and has been widely recognized as a fundamental participant in many physiological and pathological processes. The development of robust probes for indicating its existence, concentration, and especially the spatiotemporal messages in the subcellular location of live cells is emerging as one of the most intriguing research subjects. In this work, we report the design and synthesis of a new dihydropyridine-derived boron dipyrromethene (BODIPY) sensor (Lyso-DHP) modified with a morpholine unit for sensitively and selectively detecting NO in 100 % aqueous media and lysosomes of living cells. Time/pH-dependent fluorescence experiments in the presence of NO revealed Lyso-DHP was a fast-response probe in an acidic environment. Lyso-DHP showed an ultrahigh “switch-on” ratio (140-fold fluorescence enhancement) and ultralow detection of limit (LoD, 47 nM). Moreover, Lyso-DHP itself and its NO-induced aromatization product Lyso-PY were both cytocompatible. Live-cell-related localization studies including the exogenous/endogenous NO imaging and lysosome targeting demonstrated good cell permeability and feasibility and dependability for application in live cells. The obtained results indicated that Lyso-DHP was capable of tracing subcellular NO with high specificity, precision, and brightness." @default.
- W3146050608 created "2021-04-13" @default.
- W3146050608 creator A5007510363 @default.
- W3146050608 creator A5042196538 @default.
- W3146050608 creator A5055728529 @default.
- W3146050608 creator A5080909518 @default.
- W3146050608 creator A5081629380 @default.
- W3146050608 creator A5091842732 @default.
- W3146050608 date "2021-07-01" @default.
- W3146050608 modified "2023-10-09" @default.
- W3146050608 title "Lysosome-targeting BODIPY-derived Hantzsch ester for nitric oxide detection and imaging in live cells" @default.
- W3146050608 cites W1545184254 @default.
- W3146050608 cites W1967427180 @default.
- W3146050608 cites W1967978378 @default.
- W3146050608 cites W1981120411 @default.
- W3146050608 cites W1983335011 @default.
- W3146050608 cites W1990665368 @default.
- W3146050608 cites W1998319919 @default.
- W3146050608 cites W2001264372 @default.
- W3146050608 cites W2007737411 @default.
- W3146050608 cites W2013322023 @default.
- W3146050608 cites W2013652565 @default.
- W3146050608 cites W2019155443 @default.
- W3146050608 cites W2028921565 @default.
- W3146050608 cites W2036099108 @default.
- W3146050608 cites W2081595932 @default.
- W3146050608 cites W2100537204 @default.
- W3146050608 cites W2108379152 @default.
- W3146050608 cites W2151355155 @default.
- W3146050608 cites W2158523008 @default.
- W3146050608 cites W2166316639 @default.
- W3146050608 cites W2216339305 @default.
- W3146050608 cites W2231315958 @default.
- W3146050608 cites W2289711261 @default.
- W3146050608 cites W2315800446 @default.
- W3146050608 cites W2370995946 @default.
- W3146050608 cites W2395873223 @default.
- W3146050608 cites W2414226164 @default.
- W3146050608 cites W2472384909 @default.
- W3146050608 cites W2516536044 @default.
- W3146050608 cites W2528035688 @default.
- W3146050608 cites W2558945289 @default.
- W3146050608 cites W2570467237 @default.
- W3146050608 cites W2576084499 @default.
- W3146050608 cites W2592894389 @default.
- W3146050608 cites W2606687194 @default.
- W3146050608 cites W2615478621 @default.
- W3146050608 cites W2740100493 @default.
- W3146050608 cites W2740565862 @default.
- W3146050608 cites W2743471941 @default.
- W3146050608 cites W2745518803 @default.
- W3146050608 cites W2752003013 @default.
- W3146050608 cites W2755216590 @default.
- W3146050608 cites W2772565306 @default.
- W3146050608 cites W2790151735 @default.
- W3146050608 cites W2918528115 @default.
- W3146050608 cites W2923560891 @default.
- W3146050608 cites W2944094795 @default.
- W3146050608 cites W2952916205 @default.
- W3146050608 cites W2953326126 @default.
- W3146050608 cites W2955296596 @default.
- W3146050608 cites W2974548858 @default.
- W3146050608 cites W2979260210 @default.
- W3146050608 cites W2991147816 @default.
- W3146050608 cites W2999417397 @default.
- W3146050608 cites W3000620487 @default.
- W3146050608 cites W3002714089 @default.
- W3146050608 cites W3008903336 @default.
- W3146050608 cites W3012389045 @default.
- W3146050608 cites W3041723582 @default.
- W3146050608 cites W3043951089 @default.
- W3146050608 cites W3049597990 @default.
- W3146050608 cites W3127166644 @default.
- W3146050608 doi "https://doi.org/10.1016/j.snb.2021.129880" @default.
- W3146050608 hasPublicationYear "2021" @default.
- W3146050608 type Work @default.
- W3146050608 sameAs 3146050608 @default.
- W3146050608 citedByCount "23" @default.
- W3146050608 countsByYear W31460506082021 @default.
- W3146050608 countsByYear W31460506082022 @default.
- W3146050608 countsByYear W31460506082023 @default.
- W3146050608 crossrefType "journal-article" @default.
- W3146050608 hasAuthorship W3146050608A5007510363 @default.
- W3146050608 hasAuthorship W3146050608A5042196538 @default.
- W3146050608 hasAuthorship W3146050608A5055728529 @default.
- W3146050608 hasAuthorship W3146050608A5080909518 @default.
- W3146050608 hasAuthorship W3146050608A5081629380 @default.
- W3146050608 hasAuthorship W3146050608A5091842732 @default.
- W3146050608 hasConcept C121332964 @default.
- W3146050608 hasConcept C178790620 @default.
- W3146050608 hasConcept C181199279 @default.
- W3146050608 hasConcept C185592680 @default.
- W3146050608 hasConcept C2780216420 @default.
- W3146050608 hasConcept C2781374752 @default.
- W3146050608 hasConcept C519581460 @default.
- W3146050608 hasConcept C55493867 @default.
- W3146050608 hasConcept C62520636 @default.
- W3146050608 hasConcept C86803240 @default.