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- W3146057214 abstract "Background and Aim: Methicillin-Resistant Staphylococcus aureus (MRSA) had appeared in the last few decades and became a significant health problem. The study aimed to evaluate the prevalence of class 1 and class 2 integrons among MRSA clinical isolates from different healthcare-associated infections (HAIs) and the prevalence of multi-drug resistance (MDR) in these isolates. Materials and Methods: Two hundred Staphylococcus aureus ( S. aureus ) isolates from different HAIs were evaluated for the presence of the mecA gene , class 1 ( intI1 ) and class 2 ( intI2 ) integrons via the polymerase chain reaction (PCR) beside the determination of antibiotics sensitivity. Results: MRSA was determined by resistance to cefoxitin in 152 isolates (76%) of isolated S. aureus . The molecular study showed the prevalence of mecA , intI1, and intI2 genes among the isolated MRSA strains as follows: 100%, 70.4%, 13.1, respectively, and there were 12 isolates (7.9%) that had both intI1 and intI2 genes . There was a significant high incidence of resistance to gentamicin (P=0.01), amikacin (P=0.005), tobramycin (P=0.035), erythromycin (P=0.035), clindamycin (P=0.08), levofloxacin (P=0.0001) and ciprofloxacin (P=0.0001) in MRSA strains positive for intI1 and/or intI2 genes compared to MRSA strains negative for intI genes and non-methicillin resistant S. aureus (Non- MRSA) strains. There was a significantly high prevalence of MDR among MRSA strains positive for intI1 and/or intI2 genes (62.8%) compared to MRSA strains negative for intI genes (28.8%) and Non- MRSA strains (8.3%), (P=0.0001). Conclusion: The present study revealed a high prevalence of MRSA strains among S. aureus clinical isolates with a high prevalence of the mecA gene in those isolates. There was also a high prevalence of intI1 gene but not intI2 gene . The mecA and intI genes were associated with the development of MDR in S. aureus ." @default.
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- W3146057214 date "2021-01-11" @default.
- W3146057214 modified "2023-09-26" @default.
- W3146057214 title "Molecular Study of Class1 and 2 Integrons in Methicillin-resistant Staphylococcus Aureus" @default.
- W3146057214 doi "https://doi.org/10.2174/18742858-v15-e210111-2020-65" @default.
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