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- W3146057957 abstract "Progressive renal tubulointerstitial fibrosis is a common final pathway of nearly all forms of chronic kid- ney disease. Many efforts have been done to arrest or prevent renal tubulointerstitial fibrosis but with little pro- gress. Nowadays, few therapeutic agents are available in clinical use. Norcantharidin (NCTD) is of great benefit in anticancer treatment, by inducing cell apoptosis, inhibiting cell proliferation, in addition, blocking tumor metastasis and angiogenesis in cancer, whereas little attention is given to its relationship with other diseases. Our recent studies demonstrated that NCTD was protective against renal tubulointerstitial fibrosis both in vivo and in vitro. The underlying mechanisms may include modulation of TGF- b1/Smad signal cascade, inhibition of protein serine/thre- onine phosphatases (PPP) as well as NF-jB. NCTD may be a promising therapeutic agent for renal tubulointerstitial fibrosis. In the present article, we will review the action of NCTD in renal tubulointerstitial fibrosis and discuss its possible mechanisms." @default.
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- W3146057957 date "2012-01-01" @default.
- W3146057957 modified "2023-09-26" @default.
- W3146057957 title "Norcantharidin, a protective therapeutic agent in renal tubulointerstitial fibrosis" @default.
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