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- W3146060246 abstract "www.thelancet.com Vol 375 February 27, 2010 725 Authors’ reply A pharmacogenomic effect was seen in the LARGE trial: by contrast with B16 Gly/Gly patients, B16 Arg/Arg patients treated with salmeterol in LARGE did not have better methacholine res ponsiveness than did those on placebo. Although we agree that differences in haplotype may have a role in determining phenotypic differences between individuals, the lack of genotypespecific effect on morning peak expiratory flow in our white population—by contrast with previous studies—was unlikely to be due to haplotypic differences, since about 94% of white Arg/Arg are in haplotype 4. However, since only 49% of black Arg/Arg are in haplotype 4, haplotypic differences (or other epi genetic factors) could have accounted for the differences in morning peak expiratory flow seen between black patients and white patients after treatment with salmeterol." @default.
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- W3146060246 date "2010-01-01" @default.
- W3146060246 modified "2023-09-24" @default.
- W3146060246 title "Drug development for neglected diseases" @default.
- W3146060246 hasPublicationYear "2010" @default.
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