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- W3146064098 abstract "Objective To analyzed clinical significance of dectection of autoantibodies in patients with autoimmune liver disease. Methods Indirect immunofluorescent assay was used to detect anti -nuclear antibodies (ANA),antimitochondria antibodies (AMA),and anti-smooth muscle antibodies (SMA). Immune blotting assay was used to detect soluble liver antigen(SLA)/liver-pancreas antigen(LP),anti-liver kidney microtonal antibody-1(LKM-1),liver cytosolic-1 (LC-1). Enzyme-linked immune absorbent assay was used to measure subtype of AMA(M2). Results The autoimmune hepatopathy(AIH)group could be divided into 3 subtypes according to the difference of the autoantibodies asⅠ(75.4%), Ⅱ(10.3%),Ⅲ(17.2%). The positive rates of SLA/LP,LKM-1,LC-1,SMA,AMA and AMA-M2 were 20.0%,16.0%,8.0%, 52.0% ,12.0 and 4.0% respectively in patients with autoimmune hepatitis. The positive rate of SLA/LP,SMA,AMA and AMA-M2 were 2.6% ,15.4%,94.9 and 97.4% in patients with primary biliary cirrhosis (PBC) respectively. While the positive reate was 1.20% in non-autoimmune hepatopathy group. No autoantibodies associated with autoimmune liver disease were detected in PSC,non -autoimmune live diseases group and healthy group. Conclusions The AIH and PBC in autoimmune liver diseases are progressive liver inflammation accompanied with the production of characteristic antibodies. Detection of autoantibodies is clinically useful for identifying and classifying liver diseases." @default.
- W3146064098 created "2021-04-13" @default.
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- W3146064098 date "2010-01-01" @default.
- W3146064098 modified "2023-09-23" @default.
- W3146064098 title "Value of detection of autoantibodies in diagnosis of autoimmune hepatopathy patients" @default.
- W3146064098 hasPublicationYear "2010" @default.
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