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- W3146066723 abstract "瞄准：为了澄清 DNA 的可能的贡献，错配修理(MMR ) 在肝吸虫的致癌作用的系统由使用免疫的联系感染的肝内 cholangiocarcinoma (国际计算中心) 组织化学的试金。方法：29 件国际计算中心样品的一个总数，被一个基于 PCR 的方法为 genomic 不稳定性估计了，被用于学习。他们组织化学地是检验免疫表明二 MMR 基因， hMSH2 和 hMLH1 的蛋白质表示。获得的结果与他们以前估计的 mutator 显型相比。结果：hMSH2 或 hMLH1 蛋白质显然在 29 中的 28 个被表示(96.6%) 国际计算中心样品。hMSH2 或 hMLH1 蛋白质的积极原子本地化在 86.2% 被观察(25/29 ) 或 93.1%(27/29 ) 国际计算中心盒子，分别地当他们的否定原子反应仅仅在 13.8% 被检测时(4/29 ) 或 6.9%(2/29 ) 国际计算中心盒子分别地分析了。结论：我们的学习，可能第一次，通过免疫显示出那个 DNA MMR 系统不玩的 hMSH2 和 hMLH1 基因的组织化学的察觉在肝吸虫的一个突出的角色联系感染的 cholangiocarcinogenesis。这些结果在通过一个基于 PCR 的方法估计的这些基因的突变地位上证实以前的调查结果。组织化学的分析证明了是为屏蔽 MMR 缺乏不管的一条有效、敏感的途径的免疫在激活或 hMSH2 或 hMLH1 基因的倡导者 hypermethylation 体。而且，免疫组织化学以简洁，耗时的更少和为在肿瘤发生屏蔽目标 MMR 基因的可能的参与的费用有效性与 mutator phenotyping 试金相比是更有益的。" @default.
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- W3146066723 date "2006-01-01" @default.
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- W3146066723 title "Immunohistochemical expression of mismatch repair genes： A screening tool for predicting mutator phenotype in liver fluke infection-associated intrahepatic cholangiocarcinoma" @default.
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