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- W3146069269 abstract "Hashimoto’s encephalopathy is a steroid-responsive encephalopathy associated with the existence of anti-thyroid antibodies, which is characterized by various neuropsychiatric symptoms [2, 4, 6]. Autoimmune mechanisms are thought to play a pathogenic role in the disorder due to its association with other autoimmune disorders and response to steroid therapy; however the pathological mechanism underlying the disease has not been completely elucidated. We herein report a patient who manifested with steroid-responsive progressive memory disturbance, cerebellar ataxia and dystonia associated with an elevated immunoglobulin G4 (IgG4) level in both the serum and cerebrospinal fluid (CSF). The patient was a 60-year-old Japanese male who presented with a 6-month history of progressive gait disturbance. He developed memory disturbance and involuntary movements of his face and neck 2 months after presentation. There were no vascular risk factors, such as hypertension, diabetes mellitus or dyslipidemia. A neurological examination revealed cerebellar ataxia and grimacing face with cervical dystonia. Neuropsychological assessments revealed that the Mini-Mental State Examination score was 26 and the Frontal Assessment Battery score was 14, which was normal compared to age-matched normal subjects. Laboratory tests showed a high titer of anti-thyroglobulin antibodies (213 IU/ml; normal, 100) while the titer of anti-thyroid peroxidase antibodies in the serum was negative. The results of routine blood tests, the levels of antinuclear and anti-DNA antibodies, anti-SS-A/Ro, antiSS-B/La antibodies, anti-gliadin antibodies, anti-glutamic acid decarboxylase antibodies, myeloperoxidase-antineutrophil cytoplasmic antibodies (ANCA), proteinase-3ANCA, anti-voltage-gated potassium channel antibodies, angiotensin-converting enzyme, T3, T4, TSH and serum" @default.
- W3146069269 created "2021-04-13" @default.
- W3146069269 creator A5021233306 @default.
- W3146069269 date "2013-01-01" @default.
- W3146069269 modified "2023-09-24" @default.
- W3146069269 title "Hashimoto's encephalopathy associated with an elevated intrathecal IgG4 level" @default.
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