Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146073198> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3146073198 endingPage "12955" @default.
- W3146073198 startingPage "12945" @default.
- W3146073198 abstract "Hepatocellular carcinoma(HCC) is the fourth cause of cancer related mortality, and its incidence is rapidly increasing. Viral hepatitis, alcohol abuse, and exposure to hepatotoxins are major risk factors, but nonalcoholic fatty liver disease(NAFLD) associated with obesity, insulin resistance, and type 2 diabetes, is an increasingly recognized trigger, especially in developed countries. Older age, severity of insulin resistance and diabetes, and iron overload have been reported to predispose to HCC in this context. Remarkably, HCCs have been reported in non-cirrhotic livers in a higher proportion of cases in NAFLD patients than in other etiologies. Inherited factors have also been implicated to explain the different individual susceptibility to develop HCC, and their role seems magnified in fatty liver, where only a minority of affected subjects progresses to cancer. In particular, the common I148 M variant of the PNPLA3 gene influencing hepatic lipid metabolism influences HCC risk independently of its effect on the progression of liver fibrosis. Recently, rare loss-of-function mutations in Apolipoprotein B resulting in very low density lipoproteins hepatic retention and in Telomerase reverse transcriptase influencing cellular senescence have also been linked to HCC in NAFLD. Indeed, hepatic stellate cells senescence has been suggested to bridge tissue aging with alterations of the intestinal microbiota in the pathogenesis of obesity-related HCC. A deeper understanding of the mechanisms mediating hepatic carcinogenesis during insulin resistance, and the identification of its genetic determinants will hopefully provide new diagnostic and therapeutic tools." @default.
- W3146073198 created "2021-04-13" @default.
- W3146073198 creator A5023720007 @default.
- W3146073198 creator A5030444855 @default.
- W3146073198 creator A5044143383 @default.
- W3146073198 creator A5076495137 @default.
- W3146073198 creator A5081740466 @default.
- W3146073198 date "2014-01-01" @default.
- W3146073198 modified "2023-09-23" @default.
- W3146073198 title "Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors" @default.
- W3146073198 hasPublicationYear "2014" @default.
- W3146073198 type Work @default.
- W3146073198 sameAs 3146073198 @default.
- W3146073198 citedByCount "0" @default.
- W3146073198 crossrefType "journal-article" @default.
- W3146073198 hasAuthorship W3146073198A5023720007 @default.
- W3146073198 hasAuthorship W3146073198A5030444855 @default.
- W3146073198 hasAuthorship W3146073198A5044143383 @default.
- W3146073198 hasAuthorship W3146073198A5076495137 @default.
- W3146073198 hasAuthorship W3146073198A5081740466 @default.
- W3146073198 hasConcept C126322002 @default.
- W3146073198 hasConcept C134018914 @default.
- W3146073198 hasConcept C151730666 @default.
- W3146073198 hasConcept C2776175330 @default.
- W3146073198 hasConcept C2776954865 @default.
- W3146073198 hasConcept C2777391703 @default.
- W3146073198 hasConcept C2778019345 @default.
- W3146073198 hasConcept C2778772119 @default.
- W3146073198 hasConcept C2779134260 @default.
- W3146073198 hasConcept C2779343474 @default.
- W3146073198 hasConcept C555293320 @default.
- W3146073198 hasConcept C71924100 @default.
- W3146073198 hasConcept C86803240 @default.
- W3146073198 hasConceptScore W3146073198C126322002 @default.
- W3146073198 hasConceptScore W3146073198C134018914 @default.
- W3146073198 hasConceptScore W3146073198C151730666 @default.
- W3146073198 hasConceptScore W3146073198C2776175330 @default.
- W3146073198 hasConceptScore W3146073198C2776954865 @default.
- W3146073198 hasConceptScore W3146073198C2777391703 @default.
- W3146073198 hasConceptScore W3146073198C2778019345 @default.
- W3146073198 hasConceptScore W3146073198C2778772119 @default.
- W3146073198 hasConceptScore W3146073198C2779134260 @default.
- W3146073198 hasConceptScore W3146073198C2779343474 @default.
- W3146073198 hasConceptScore W3146073198C555293320 @default.
- W3146073198 hasConceptScore W3146073198C71924100 @default.
- W3146073198 hasConceptScore W3146073198C86803240 @default.
- W3146073198 hasIssue "36" @default.
- W3146073198 hasLocation W31460731981 @default.
- W3146073198 hasOpenAccess W3146073198 @default.
- W3146073198 hasPrimaryLocation W31460731981 @default.
- W3146073198 hasRelatedWork W1977479947 @default.
- W3146073198 hasRelatedWork W2004035484 @default.
- W3146073198 hasRelatedWork W2036443974 @default.
- W3146073198 hasRelatedWork W2065617900 @default.
- W3146073198 hasRelatedWork W2095866442 @default.
- W3146073198 hasRelatedWork W2144055091 @default.
- W3146073198 hasRelatedWork W2182023079 @default.
- W3146073198 hasRelatedWork W2274766370 @default.
- W3146073198 hasRelatedWork W2464175445 @default.
- W3146073198 hasRelatedWork W2592570884 @default.
- W3146073198 hasRelatedWork W2769242138 @default.
- W3146073198 hasRelatedWork W2791183307 @default.
- W3146073198 hasRelatedWork W2894729317 @default.
- W3146073198 hasRelatedWork W2910470553 @default.
- W3146073198 hasRelatedWork W2951821865 @default.
- W3146073198 hasRelatedWork W2964488832 @default.
- W3146073198 hasRelatedWork W3089591400 @default.
- W3146073198 hasRelatedWork W3107498091 @default.
- W3146073198 hasRelatedWork W3139636356 @default.
- W3146073198 hasRelatedWork W3160163020 @default.
- W3146073198 isParatext "false" @default.
- W3146073198 isRetracted "false" @default.
- W3146073198 magId "3146073198" @default.
- W3146073198 workType "article" @default.