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- W3146074453 abstract "Abstract Background Prolongation of the ECG derived QT interval predicts increased risk for sudden life-threatening arrhythmias. Many medicines are known to prolong the QT interval though current data demonstrate that progesterone given to premenopausal females 18 years old. The effects of this treatment on the corrected QT (QTc) in this population are unknown. Objective To describe the effect of exogenous progestin on the QTc in adolescent females. Methods In post-menarcheal females, Results There were 40 controls and 21 treated participants. The age range was 10 – 17 years. There were no differences between the groups with regard to race, height, weight, BMI, or blood pressure. In the controls, the mean QTc was 403 +/-19 milliseconds (ms) vs. 397 +/-15 ms in those treated (p=0.22). Those on progestin therapy had a shorter QTc by the same magnitude difference (six ms) as the hormonal naive group in the adult literature. Conclusions We report no adverse effects of progestin associated with QTc prolongation and a trend suggesting a decreased QTc in a population of post menarcheal-adolescent females." @default.
- W3146074453 created "2021-04-13" @default.
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- W3146074453 date "2021-01-01" @default.
- W3146074453 modified "2023-09-27" @default.
- W3146074453 title "The Effects of Progestin-Only Hormone Treatment on QT Interval in the Adolescent Female" @default.
- W3146074453 hasPublicationYear "2021" @default.
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