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- W3146075388 abstract "Objective:To observe effects of the plasmids expressing interleukin 12 and interleukin 18 on the humoral immune responses in Balb/c(H 2d)mice induced by DNA immunization of HBV core gene. Methods:The DNA vaccine of HBV core gene,the plasmids expressing interleukin 12 and interleukin 18 were simultaneously immunized by intramuscular injection in Balb/c mice.The levels of anti HBc antibody and its isotypes (IgG1,IgG2a)were detected by ELISA methods.Results: Six weeks after the 1st immunization, the levels of anti HBc antibody in groups of mice immunized with HBV core DNA vaccine plus the plasmids expressing interleukin 12 or interleukin 18 or both interleukin 12 and interleukin 18 were all much hugher than those in groups of mice immunized with HBV core DNA vaccine alone(P 0.05).In analysis of IgG subgroups the IgG2a was generally higher than IgG1 in all groups of mice immunized with DNA vaccines mentioned aboue. Conclusion:The plasmids expressing interleukin 12 and interleukin 18 may enhance the specific humoral immune responses induced by immunization with HBV core DNA vaccine." @default.
- W3146075388 created "2021-04-13" @default.
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- W3146075388 date "2002-01-01" @default.
- W3146075388 modified "2023-09-25" @default.
- W3146075388 title "Effects of the Plasmids Expressing Interleukin 12 and 18 on Humoral Immune Responses in H-2~d Mice Induced by DNA Immunization of HBV Core Gene" @default.
- W3146075388 hasPublicationYear "2002" @default.
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